Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder

Patent metadata

Field	Value
Publication number	US-10918632-B2
Application number	US-201716330469-A
Country	US
Kind code	B2
Filing date	Sep 6, 2017
Priority date	Sep 7, 2016
Publication date	Feb 16, 2021
Grant date	Feb 16, 2021

Abstract

This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).

First claim

What is claimed is:

1. A method of treating an eating disorder in a subject comprising administering a therapeutically effective amount of fasoracetam or fasoracetam monohydrate to a subject having at least one genetic alteration in a mGluR network gene, wherein said eating disorder is selected from anorexia nervosa (AN) and binge eating disorder (BED), thereby treating AN and/or BED.

2. The method of claim 1 , wherein the genetic alteration is a duplication or deletion copy number variation (CNV).

3. The method of claim 1 , wherein the genetic alteration is in at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50, 60, 70, or all Tier 1 mGluR network genes.

4. The method of claim 1 , wherein the genetic alteration is in at least 2, 3, 4, 5, 10, 20, 30, 50, 100, 150, 175, or all Tier 2 mGluR network genes or in at least 2, 3, 4, 5, 10, 20, 50, 100, 200, 300, 400, 500, or all Tier 3 mGluR network genes.

5. The method of claim 1 , wherein the genetic alteration is in one or more genes in the mGluR network at the corresponding chromosomal regions listed in FIGS. 1 to 3 .

6. The method of claim 1 , wherein the genetic alteration is not in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7 or GRM8.

7. The method of claim 1 , wherein the subject has a genetic alteration in at least two mGluR network genes.

8. The method of claim 1 , wherein the subject has the bingeing and/or purging subtype of AN or the restricting subtype of AN.

9. The method of claim 1 , wherein the subject is a pediatric subject, an adolescent subject, or an adult subject.

10. The method of claim 1 , wherein the fasoracetam or fasoracetam monohydrate is administered at a dose of 50-400 mg, and wherein the dose is administered once, twice, or three times daily.

11. The method of claim 9 , wherein the subject is already taking or is administered one or more antidepressant, anxiolytic or anti-psychotic.

12. The method of claim 11 , wherein the antidepressant is fluoxetine, escitalopram, bupropion, mirtazapine, amitriptyline, imipramine, venlafaxine, sertraline, paroxetine, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitors, or monoamine oxidase inhibitors and the anxiolytic is a barbiturate, pregabalin, benzodiazepine, chlordiazepoxide, clorazepate, diazepam, flurazepam, halazepam, prazepam, lorazepam, lormetazepam, oxazepam, temazepam, clonazepam, flunitrazepam, nimetazepam, nitrazepam, adinazolam, alprazolam, estazolam, triazolam, climazolam, loprazolam, or midazolam and the anti-psychotic is olanzapine, quetiapine, aripiprazole or risperidone.

13. The method of claim 1 , wherein the fasoracetam or fasoracetam monohydrate is administered in combination with at least one non-pharmaceutical therapy, selected from, vagus nerve stimulation, repetitive transcranial magnetic stimulation, magnetic seizure therapy, and deep brain stimulation.

14. The method of claim 1 , wherein the genetic alteration is detected by a process comprising administering a genetic test comprising obtaining a sample from the subject, optionally isolating nucleic acid from the sample, optionally amplifying the nucleic acid, and analyzing the nucleic acid for a genetic alteration in at least one Tier 1, Tier 2 or Tier 3 mGluR network gene.

15. The method of claim 14 , further comprising obtaining results of the genetic test prior to initial administration of the fasoracetam or fasoracetam monohydrate.

16. The method of claim 14 , wherein the genetic test does not assess CNVs or SNVs in one or more of GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7 or GRM8.

Assignees

• Childrens Hospital Philadelphia

Inventors

• Hakonarson Hakon
• Kao Charlly

Classifications

• C12Q2600/156

  Polymorphic or mutational markers · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• C12Q1/6883

  for diseases caused by alterations of genetic material · CPC title

• C12Q2600/106

  Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title