Compact microscope
US-2018143418-A1 · May 24, 2018 · US
US10914665B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10914665-B2 |
| Application number | US-201916697373-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 27, 2019 |
| Priority date | Nov 17, 2015 |
| Publication date | Feb 9, 2021 |
| Grant date | Feb 9, 2021 |
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Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.
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What is claimed is: 1. An entity discrimination apparatus comprising: a sample arranging unit configured to accommodate a sample taken from a target entity; an environmental chamber configured to accommodate the sample arranging portion therein and change an environmental condition surrounding the sample; a wave source configured to irradiate a wave towards the sample in the sample arranging portion; one or more detectors configured to detect a laser speckle that is generated by multiple scattering of the irradiated wave due to the sample, at every predetermined time point; and a controller configured to estimate concentrations of microbes in the sample by using the detected laser speckle before and after the environmental condition is changed, and discriminate the target entity from among a plurality of entities by using a difference between the estimated concentrations of the microbes before and after the environmental condition is changed, and wherein the controller comprises: an average concentration estimator configured to obtain a temporal correlation of the detected laser speckle by using the detected laser speckle, and estimate an average concentration of one or more kinds of microbes included in the sample based on the obtained temporal correlation; and an identifier configured to generate discrimination data by calculating a variation rate of the average concentration of the microbes according to the change in the environmental condition, and discriminate the target entity by using the discrimination data. 2. The entity discrimination apparatus of claim 1 , further comprising a data storage in which reference data about the variation rate of the average concentration of the microbes according to the change in the environmental condition is stored in advance, wherein the identifier is further configured to discriminate the target entity from among the plurality of entities by comparing the discrimination data and the reference data. 3. The entity discrimination apparatus of claim 2 , wherein the controller is further configured to, when the target entity is acknowledged in advance, determine a health condition of the target entity by comparing the discrimination data of the target entity and the reference data. 4. The entity discrimination apparatus of claim 1 , wherein the wave source is arranged on an outer portion of the environmental chamber. 5. The entity discrimination apparatus of claim 4 , wherein a surface of the environmental chamber on a path through which the wave is irradiated includes a transparent material. 6. The entity discrimination apparatus of claim 4 , wherein a surface of the environmental chamber on a path through which the wave is irradiated includes a diffusion material for diffusing the wave. 7. The entity discrimination apparatus of claim 1 , wherein the environmental chamber is configured such that at least one of a temperature, humidity, pressure, and a magnetic field is changeable.
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