Compositions and methods of treating retinal disease

Patent metadata

Field	Value
Publication number	US-10913722-B2
Application number	US-201916241851-A
Country	US
Kind code	B2
Filing date	Jan 7, 2019
Priority date	May 26, 2005
Publication date	Feb 9, 2021
Grant date	Feb 9, 2021

Abstract

Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed

First claim

What is claimed:

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 which is:

or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound selected from the group consisting of:

and a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

6. The pharmaceutical composition of claim 5 , wherein the compound is:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

7. The pharmaceutical composition of claim 5 , wherein the compound is:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

8. The pharmaceutical composition of claim 5 , wherein the compound is:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Assignees

• Aldeyra Therapeutics Inc

Inventors

• Jordan Thomas A
• Dowling John E
• Chabala John Clifford

Classifications

• C07D277/56 Primary

  Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen · CPC title

• A61K31/41

  having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title

• C07C215/68

  having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton · CPC title

• A61K31/423

  condensed with carbocyclic rings · CPC title

• C07D215/38 Primary

  Nitrogen atoms (nitro radicals C07D215/18) · CPC title