Microfluidic mixer

Patent metadata

Field	Value
Publication number	US-10913039-B2
Application number	US-201616300975-A
Country	US
Kind code	B2
Filing date	Jul 6, 2016
Priority date	Jul 6, 2016
Publication date	Feb 9, 2021
Grant date	Feb 9, 2021

Abstract

One example provides a microfluidic mixing device that includes a main fluidic channel to provide main fluidic channel flow and a number of I-shaped secondary channels extending outwardly from a portion of the main fluidic channel. A number of inertial pumps are located within the I-shaped secondary channels to create serpentine flows in the direction of the main fluidic channel flow or create vorticity-inducing counterflow in the main fluidic channel.

First claim

What is claimed is:

1. A microfluidic mixing device comprising:
a main fluidic channel to provide main fluidic channel flow;
a plurality of I-shaped secondary channels extending outwardly from a portion of the main fluidic channel; and
a number of secondary-channel inertial pumps located within the I-shaped secondary channels to create serpentine flows in the direction of the main fluidic channel flow or create vorticity-inducing counterflow in the main fluidic channel;
wherein at least one of the secondary-channel inertial pumps is actuated based on a velocity of fluid in the main fluidic channel and on an axial offset distance between successive secondary channels, such that a volume of fluid longitudinally traversing the main fluidic channel and extending a length that is longer than the axial offset distance is mixed by the action of the at least one secondary-channel inertial pump.

2. The microfluidic mixing device of claim 1 , wherein the main fluidic channel further comprises a number of inertial pumps asymmetrically located within the main fluidic channel to create the main fluidic channel flow.

3. The microfluidic mixing device of claim 1 , wherein at least two of the secondary channels extend from the main fluidic channel to define I-shaped secondary channels that are located axially offset from each other on opposite sides of the main fluidic channel, wherein a largest width portion of the main fluidic channel defines a largest-width boundary spaced a distance from and extending parallel to a longitudinal axis of the main fluidic channel, and wherein at least one of the I-shaped secondary channels has an opening that provides fluid communication with the main fluidic channel, a distance between the opening and the longitudinal axis being less than the distance between longitudinal axis and the largest-width boundary, the I-shaped secondary channels to create the serpentine flows in the direction of the main fluidic channel flow.

4. The microfluidic mixing device of claim 1 , wherein a number of the secondary channels extend obliquely from the main fluidic channel at an obtuse or acute angle with respect to a longitudinal axis of the main fluidic channel to create the vorticity-inducing counterflow in the main fluidic channel.

5. The microfluidic mixing device of claim 4 , wherein the number of the secondary channels include at least one obtusely angled secondary channel and at least one acutely angled second channel.

6. The microfluidic mixing device of claim 4 , wherein at least two of the plurality of I-shaped secondary channels are obliquely angled in the same direction with respect to a longitudinal axis of the main fluidic channel.

7. The microfluidic mixing device of claim 4 wherein at least two of the plurality of I-shaped secondary channels are located axially offset from each other on approximately opposite sides of the main fluidic channel with respect to a longitudinal axis of the main fluidic channel.

8. The microfluidic mixing device of claim 4 , wherein a number of the secondary channels extend transversely from the main fluidic channel perpendicular to the longitudinal axis of the main fluidic channel.

9. A microfluidic mixing system comprising:
a microfluidic mixing device comprising:
a main fluid mixing channel;
a number of I-shaped secondary channels extending from the main fluid mixing channel; and
a number of inertial pumps located in the secondary channels to pump fluids within the secondary channels,
wherein the I-shaped secondary channels produce a flood and drain flow into and out of the I-shaped secondary channels to create serpentine flows in the direction of the main fluid mixing channel flow or to create vorticity-inducing counterflow in the main fluid mixing channel;

a fluid source; and
a control device to provide fluids from the fluid source to the microfluidic mixing device and activate the secondary-channel inertial pumps;
wherein at least two of the secondary channels extend from the main fluid mixing channel to define I-shaped secondary channels that are located axially offset from each other on opposite sides of the main fluid mixing channel, wherein the largest width of the main fluid mixing channel defines a boundary extending the length of the main fluid mixing channel, and wherein at least one of the I-shaped secondary channels has an opening to the main fluidic channel that originates at a position within a portion of the main fluidic channel, a distance between the opening and the largest-width boundary being less than the distance between the main fluidic channel center and the largest-width boundary, the I-shaped secondary channels to create the serpentine flows in the direction of the main fluid mixing channel flow.

10. The system of claim 9 , in which the main fluid mixing channel contains a number of inertial pumps asymmetrically placed in main fluid mixing channel to create main flow.

11. The system of claim 9 , wherein a number of the secondary channels extend from the main fluid mixing channel at an obtuse or acute angle with respect to a longitudinal axis of the main fluid mixing channel to create the vorticity-inducing counterflow in the main fluid mixing channel.

12. A method of controlling a microfluidic mixer, the method comprising:
activating a number of secondary-channel inertial pumps located within a number of I-shaped secondary channels fluidly coupled to a main microfluidic channel to pump fluids through the secondary channels, wherein at least two I-shaped secondary channels extend from the main microfluidic channel, wherein the inertial pumps located within the I-shaped secondary channels create serpentine flows in the direction of the main microfluidic channel flow or to create vorticity-inducing counterflow in the main microfluidic channel; and
activating an inertial pump within a first I-shaped secondary channel located axially offset from, and on opposite sides of the main microfluidic channel from, a second I-shaped secondary channel, at a different time with respect to activation of an inertial pump in the second I-shaped secondary channel, to create the serpentine flows in the direction of the main microfluidic channel flow.

Assignees

• Hewlett Packard Development Co

Inventors

• Govyadinov Alexander
• Kornilovich Pavel
• Torniainen Erik D
• Markel David P

Classifications

• B01F31/57 Primary

  for material continuously moving therethrough (B01F31/29, B01F31/30, B01F31/401, B01F31/46, B01F31/84 take precedence) · CPC title

• B01F2025/91913

  with feed openings facing each other, e.g. for creating counter flows, for creating a series of vortex flows · CPC title

• B01F2101/23

  Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials · CPC title

• B01F2025/9191

  characterised by the arrangement of the feed openings for one or more flows, e.g. for the mainflow and the flow of an additional component · CPC title

• B01F2025/918

  Counter current flow, i.e. flows moving in opposite direction and colliding · CPC title