Apparatus for the extracorporeal removal of protein-bound toxins

Patent metadata

Field	Value
Publication number	US-10912877-B2
Application number	US-201515328326-A
Country	US
Kind code	B2
Filing date	Jul 20, 2015
Priority date	Jul 23, 2014
Publication date	Feb 9, 2021
Grant date	Feb 9, 2021

Abstract

The present invention relates to an apparatus for the extracorporeal removal of protein-bound toxins from blood comprising at least one blood purification apparatus, in particular at least one dialysis machine, hemofilter or adsorber, as well as at least one means for generating a field in the blood purification apparatus and/or in an element in flow communication with the blood purification apparatus, in particular in a line section connected to the blood purification apparatus, wherein the means comprises at least two strip conductors which are arranged on at least two preferably oppositely disposed sides of the blood purification apparatus or of the element such that the field is preferably predominantly generated within the blood purification apparatus or preferably predominantly within the element.

First claim

The invention claimed is:

1. An apparatus for the extracorporeal removal of protein-bound toxins from blood comprising
at least one blood purification apparatus selected from the group consisting of a dialysis machine, a hemofilter, and an adsorber, wherein each of said dialysis machine, hemofilter, and adsorber have, respectively, an outer side comprising a first side and a second side, such that the first side is opposite the second side,
an element in flow communication with the at least one blood purification apparatus, wherein the element is a line section connected to the at least one blood purification apparatus, wherein said element has an outer side comprising a first side and a second side, such that the first side of the element is opposite the second side of the element,
at least one means for generating a field configured to generate a field in one or more of the element and the at least one blood purification apparatus, such that the field is predominantly generated within at least one of the at least one blood purification apparatus and the element characterized in that each of the means comprises at least two strip conductors arranged on either the outer side of one of the element or the outer side of the at least one blood purification apparatus such that at least one of the at least two strip conductors is on the first side of the outer side and at least one of the at least two strip conductors in on the second side of the outer side,
wherein, for each strip conductor, an aqueous gel is located between said strip conductor and the outer side on which it resides such that no air is located between the strip conductor and the outer side, and
wherein the field is an electromagnetic field and also wherein the field is configured to separate uremic toxins from proteins so that a proportion of free uremic toxins can be increased.

2. An apparatus in accordance with claim 1 , characterized in that the means for generating a field are configured such that an electromagnetic field is generated having a frequency in the range from 1 MHz to 1 GHz.

3. An apparatus in accordance with claim 1 , characterized in that the means for generating a field are configured such that an electromagnetic field is generated having a frequency in the range from 110 to 111 MHz.

4. An apparatus in accordance with claim 1 , characterized in that the means for generating a field is configured such that the field has a field strength in the range from up to 4000 V/m.

5. An apparatus in accordance with claim 1 , characterized in that the blood treatment apparatus or the element has a curved surface at least regionally; and in that the strip conductors are likewise curved so that they follow the contour of the surface of the blood treatment apparatus or of the element.

6. An apparatus in accordance with claim 1 , characterized in that the means extends over the total length of the blood treatment apparatus or of the element or over a part of the total length.

7. An apparatus in accordance with claim 1 , further comprising at least one extracorporeal circuit in which the blood treatment apparatus is located.

8. An apparatus in accordance with claim 7 , characterized in that the extracorporeal circuit comprises at least one filter which comprises a permeate side and a retentate side, with the blood treatment apparatus or the element being in flow communication with the permeate side.

9. An apparatus in accordance with claim 1 , characterized in that the means for generating a field are configured such that an electromagnetic field is generated having a frequency in the range from 1 MHz to 1 GHz.

10. An apparatus in accordance with claim 1 , characterized in that the means for generating a field are configured such that an electromagnetic field is generated having a frequency in the range from 50 MHz to 200 MHz.

11. An apparatus in accordance with claim 1 , characterized in that the means for generating a field is configured such that the field has a field strength in the range in the range from 2000 V/m to 4000 V/m.

12. An apparatus in accordance with claim 1 , characterized in that the means for generating a field is configured such that the field has a field strength in the range from 3000 V/m to 3200 V/m.

13. An apparatus in accordance with claim 1 , characterized in that the means extends over more than half the length of the blood treatment apparatus or of the element.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Fabig Anselm
• Tschulena Ulrich
• Steppan Sonja

Classifications

• A61M1/3472

  with treatment of the filtrate · CPC title

• A61M1/3486

  Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents · CPC title

• A61M1/3681 Primary

  by irradiation · CPC title

• A61M1/16

  with membranes · CPC title

• A61M1/3479

  by dialysing the filtrate · CPC title