Medical material, medical separation membrane, and blood purifier

Patent metadata

Field	Value
Publication number	US-10912868-B2
Application number	US-201716325429-A
Country	US
Kind code	B2
Filing date	Aug 22, 2017
Priority date	Aug 31, 2016
Publication date	Feb 9, 2021
Grant date	Feb 9, 2021

Abstract

A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.

First claim

The invention claimed is:

1. A medical separation membrane, a blood circuit, a blood storage bag, a catheter, a stent, a contact lens or a biosensor in which a medical material is bonded or attached to a surface of a membrane including a hydrophobic polymer,
wherein the medical material is a copolymer comprising a hydrophobic unit and a hydrophilic unit,
the hydrophobic unit has a terminal alkyl group having 2 to 20 carbon atoms in a side chain,
a static contact angle of water on the copolymer is 30 degrees or more and less than 70 degrees, and
the copolymer has only one glass transition temperature of 45° C. or higher and lower than 90° C.

2. The medical material according to claim 1 , wherein the hydrophobic unit is an alkyl carboxylic acid vinyl ester unit.

3. The medical material according to claim 1 , wherein the hydrophilic unit is a vinylpyrrolidone unit.

4. The medical material according to claim 1 , wherein
the static contact angle of water on the copolymer is 34 degrees or more and less than 50 degrees, and
the copolymer has only one glass transition temperature of 70° C. or higher and lower than 88° C.

5. The medical separation membrane according to claim 4 , wherein
the static contact angle of water on the hydrophobic polymer is 70 degrees or more and less than 160 degrees, and
the glass transition temperature of the hydrophobic polymer is 50° C. or higher and lower than 250° C.

6. The medical separation membrane according to claim 4 , wherein the hydrophobic polymer includes a polymer selected from the group consisting of a polysulfone-based polymer, a polymethacrylate-based polymer, a polyacrylate-based polymer, a polyester-based polymer and a polystyrene-based polymer.

7. A blood purifier including the medical separation membrane according to claim 4 .

8. The medical material according to claim 2 , wherein the hydrophilic unit is a vinylpyrrolidone unit.

9. The medical material according to claim 2 , wherein
the static contact angle of water on the copolymer is 34 degrees or more and less than 50 degrees, and
the copolymer has only one glass transition temperature of 70° C. or higher and lower than 88° C.

10. The medical material according to claim 3 , wherein
the static contact angle of water on the copolymer is 34 degrees or more and less than 50 degrees, and
the copolymer has only one glass transition temperature of 70° C. or higher and lower than 88° C.

11. A medical separation membrane in which the medical material according to claim 2 is bonded or attached to a surface of a membrane including a hydrophobic polymer.

12. A medical separation membrane in which the medical material according to claim 3 is bonded or attached to a surface of a membrane including a hydrophobic polymer.

13. A medical separation membrane in which the medical material according to claim 4 is bonded or attached to a surface of a membrane including a hydrophobic polymer.

14. The medical separation membrane according to claim 5 , wherein the hydrophobic polymer includes a polymer selected from the group consisting of a polysulfone-based polymer, a polymethacrylate-based polymer, a polyacrylate-based polymer, a polyester-based polymer and a polystyrene-based polymer.

15. A blood purifier including the medical separation membrane according to claim 5 .

16. A blood purifier including the medical separation membrane according to claim 6 .

Assignees

• Toray Industries

Inventors

• Ushiro Suguru
• Hayashi Akihiro
• Ueno Yoshiyuki

Classifications

• C08F226/10 Primary

  N-Vinyl-pyrrolidone · CPC title

• B01D71/441

  Polyvinylpyrrolidone · CPC title

• C08F220/54

  Amides {, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide} · CPC title

• C08F220/1802

  C2-(meth)acrylate, e.g. ethyl (meth)acrylate · CPC title

• A61L2400/02

  Treatment of implants to prevent calcification or mineralisation in vivo · CPC title