Vital signs monitor

Patent metadata

Field	Value
Publication number	US-10898084-B2
Application number	US-201715474937-A
Country	US
Kind code	B2
Filing date	Mar 30, 2017
Priority date	Mar 31, 2016
Publication date	Jan 26, 2021
Grant date	Jan 26, 2021

Abstract

An apparatus comprising a wearable device comprising a supporting structure, a sensor and an electronics module, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the electronics module is configured to quantify and/or transmit one or more signal(s) corresponding to the biological metric. Some aspects relate to a method of monitoring a biological metric in a subject comprising: adorning a subject with the wearable device; and detecting the biological metric over a period of time in the subject with the wearable device. Other aspects relate to a method of treating a disease in a subject comprising: monitoring a biological metric in the subject over a period of time, and treating the subject with a therapeutic protocol, and monitoring the biological metric in the subject to assess treatment efficacy. Method are provided for estimating a central aortic pressure waveform in a subject comprising: measuring a radial artery pressure waveform in the subject and transforming the radial artery pressure waveform to a central aortic pressure waveform using a transfer function.

First claim

What is claimed is:

1. A method of estimating a central aortic pressure waveform in a subject comprising:
measuring a radial artery pressure waveform in the subject by using an apparatus comprising a wearable device comprising:
(a) a supporting structure;
(b) a sensor comprising a sensing modality selected from the group consisting of:
a thin film strain gauge,
a one-dimensional structure, and
a planar structure; or
two of the sensing modalities in a face-to-face configuration;

(c) a processor; and
(d) a transmitter;

wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the processor is configured to quantify one or more signal(s) corresponding to the biological metric and the transmitter is configured to transmit the one or more signals to an external user system, and
transforming the radial artery pressure waveform to a central aortic pressure waveform using a transfer function.

2. The method according to claim 1 , wherein the transfer function describes the properties of a system on the basis of its immediate past input and output data.

3. The method according to claim 2 , wherein the transfer function uses the relation:
T ( t )=− a 1 T ( t− 1)− a 2 T ( t− 2)− . . . − a na T ( t−na )+ b 1 P ( t− 1)+ . . . + b nb P ( t−nb )  (1)

where T(t) and T(t−I) [I=1, 2 . . . na] are present and are previous output (radial tonometer) discrete measurements, respectively, and P(t−I) are previous input (aortic pressure) discrete measurements, a 1 , a 2 , a na and b nb are parameters of the model, and na and nb represent a number of previous input-output values used to describe the present output.

4. The method according to claim 1 , wherein the wearable device further comprises:
memory, and
a battery.

5. The method according to claim 4 , wherein the processor, memory, battery and transmitter are comprised within a housing disposed on an inner or an outer side of the supporting structure.

6. The method according to claim 4 , wherein the transfer function describes the properties of a system on the basis of its immediate past input and output data.

7. The method according to claim 6 , wherein the transfer function uses the relation:
T ( t )=− a 1 T ( t− 1)− a 2 T ( t− 2)− . . . − a na T ( t−na )+ b 1 P ( t− 1)+ . . . + b nb P ( t−nb )  (1)

where T(t) and T(t−I) [I=1, 2 . . . na] are present and are previous output (radial tonometer) discrete measurements, respectively, and P(t−I) are previous input (aortic pressure) discrete measurements, a 1 , a 2 , a na and b nb are parameters of the model, and na and nb represent a number of previous input-output values used to describe the present output.

Assignees

• Univ California

Inventors

• Khine Michelle
• Eckmann Nicole
• Veliz Kimberly
• Pegan Jonathan
• Kim Joshua
• Park Sun-Jun

Classifications

• A61B5/6824

  Arm or wrist · CPC title

• A61B2562/0261

  Strain gauges · CPC title

• A61B2562/12

  Manufacturing methods specially adapted for producing sensors for in-vivo measurements · CPC title

• A61B2562/0285

  Nanoscale sensors · CPC title

• A61B5/14542

  for measuring blood gases (A61B5/14551 takes precedence) · CPC title