Production method for 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane)
US-10683252-B2 · Jun 16, 2020 · US
US10882809B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10882809-B2 |
| Application number | US-201716474112-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 15, 2017 |
| Priority date | Dec 29, 2016 |
| Publication date | Jan 5, 2021 |
| Grant date | Jan 5, 2021 |
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A halogenated α-fluoroether of the formula (2) (where HaloR represents haloalkyl; R 1 represents hydrogen, halogen, alkyl or substituted alkyl; and R 2 represents alkyl or substituted alkyl) is produced efficiently on an industrial scale by reacting a halogenated aldehyde of the formula (1) (where HaloR represents haloalkyl) or an equivalent thereof with hydrogen fluoride.
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The invention claimed is: 1. A method for producing a halogenated α-fluoroether of the formula [2], comprising reacting a halogenated aldehyde of the formula [4] or an equivalent thereof with hydrogen fluoride where HaloR represents a haloalkyl group where HaloR represents a haloalkyl group; R 1 represents a hydrogen atom, a halogen atom, an alkyl group or a substituted alkyl group; and R 2 represents an alkyl group or a substituted alkyl group, wherein the reacting is conducted in the presence of an orthoester of the formula [3] where R 3 represents a hydrogen atom, an alkyl group, a substituted alkyl group or an aryl group; and R 4 represents an alkyl group or a substituted alkyl group. 2. The method according to claim 1 , wherein the equivalent of the halogenated aldehyde is a halogenated hemiacetal of the formula [1] where HaloR represents a haloalkyl group; R 1 represents a hydrogen atom, a halogen atom, an alkyl group or a substituted alkyl group; and R 2 represents an alkyl group or a substituted alkyl group. 3. The method according to claim 1 , wherein the reacting is conducted without the use of an organic solvent.
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