Compositions and methods for diagnosing and treating endometriosis-related infertility

Patent metadata

Field	Value
Publication number	US-10877045-B2
Application number	US-201615745920-A
Country	US
Kind code	B2
Filing date	Jul 20, 2016
Priority date	Jul 21, 2015
Publication date	Dec 29, 2020
Grant date	Dec 29, 2020

Abstract

Disclosed are methods of diagnosing and treating endometriosis, and in particular, endometriosis-associated infertility.

First claim

What is claimed is:

1. A method of treating endometriosis-related infertility in a subject comprising administering to said subject an inhibitor of SIP synthesis selected from the group consisting of Fingolimod, BAF312, Ponesimod, ONO-4641, CS-0777, KRP-203, PF-991, W146, and combinations thereof or an inhibitor of SIP-binding to an SIP receptor wherein the inhibitor of SIP-binding to the SIP receptor is LT1009.

2. The method of claim 1 , wherein said inhibitor inhibits the expression or activity of at least one of SPHK1, SPHK2, SGPP1, SGPP2, SGPL1, SPHKAP, SIPR1, S1PR 2 , S1PR 3 , S1PR 4 , and S1PR 5 .

3. The method of claim 1 , wherein said inhibitor inhibits binding of SIP to the SIP receptor.

4. The method of claim 1 , wherein treating reduces one or more symptoms of endometriosis.

5. The method of claim 4 , wherein said one or more symptoms are selected from the group consisting of pain, diarrhea, dysuria, constipation, chronic fatigue, nausea, vomiting, headaches, low-grade fevers, heavy and/or irregular periods, hypoglycemia or infertility.

6. The method of claim 1 , wherein said subject is a human or non-human mammal.

7. The method of claim 1 , wherein administering comprises oral, sublingual, transdermal, vaginal, intramuscular or subcutaneous injection.

8. The method of claim 7 , wherein the oral administration is by pill or tablet, the transdermal administration is by patch, cream, gel or lotion, the vaginal administration is by suppository or gel, and systemic administration.

9. The method of claim 1 , further comprising repeated administering of said inhibitor.

10. The method of claim 1 , further comprising administering a second endometriosis-related infertility treatment to said subject.

11. The method of claim 10 , wherein said second endometriosis-related infertility treatment is selected from hormonal therapy and/or surgical therapy.

Assignees

• Univ Saint Louis

Inventors

• Yeung Jr Patrick
• Salvemini Daniela

Classifications

• G01N2333/91215

  with a definite EC number (2.7.1.-) · CPC title

• C12Q1/6883

  for diseases caused by alterations of genetic material · CPC title

• G01N2800/52

  Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title

• G01N2333/726

  G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH · CPC title

• G01N33/689 Primary

  related to pregnancy or the gonads · CPC title