Process for preparing 2-exo-(2-methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane

Patent metadata

Field	Value
Publication number	US-10875873-B2
Application number	US-201816485563-A
Country	US
Kind code	B2
Filing date	Feb 5, 2018
Priority date	Feb 15, 2017
Publication date	Dec 29, 2020
Grant date	Dec 29, 2020

Abstract

This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I), (I) any one of its individual enantiomers or any non-racemic mixture thereof comprising the steps of (a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), (II) any one of its individual enantiomers or any non-racemic mixture thereof in the presence of at least one base of the formula [Mm+]n [An-]m (III) wherein Mm+ represents a m-valent metal cation wherein m is an integer of 1 or 2, and An_ represents a n-valent anion wherein n is an integer of 1 or 2, said base being capable of forming a solvent S1 selected from water, a C1-C4 alkyl alcohol or any combination thereof under the reaction conditions, to form a metal alkoxide or metal alkoxide solvate of the formula (IV), (IV) any one of its individual enantiomers or any non-racemic mixture thereof wherein M m+ , m and the solvent S1 have the same meaning as defined for the base of formula (III), and x denotes a number from 0 to 10, and (b) reacting the metal alkoxide or metal alkoxide solvate of the formula (IV), any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (V), (V) wherein X is a leaving group, wherein the steps (a) and (b) are conducted in the presence of at least one inert organic solvent S2 and comprise a further step of (c) simultaneously removing the solvent S1 from the reaction mixture.

First claim

The invention claimed is:

1. A process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I)

any one of its individual enantiomers or any non-racemic mixture thereof, the process comprising the steps of
(a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II)

any one of its individual enantiomers or any non-racemic mixture thereof
in the presence of at least one base of the formula [M m+ ] n , [A n− ] m (III) wherein M m+ represents a m-valent metal cation which is an alkali metal cation wherein m is 1, and A n− represents a n-valent anion which is hydroxide wherein n is 1, said base being capable of forming a solvent S1 which is water under the reaction conditions, to form a metal alkoxide or metal alkoxide solvate of the formula (IV)

any one of its individual enantiomers or any non-racemic mixture thereof wherein M m+ , m and the solvent S1 have the same meaning as defined for the base of formula (III), and x denotes a number from 0 to 10, and

(b) reacting the metal alkoxide or metal alkoxide solvate of the formula (IV), any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (V)

wherein X is a leaving group,

wherein the steps (a) and (b) are conducted in the presence of at least one inert organic solvent S2 selected from aromatic hydrocarbons and comprise a further step of (c) simultaneously removing the solvent S1 from the reaction mixture.

2. The process according to claim 1 wherein, in further step (c), the solvent S1 is removed from the reaction mixture by azeotropic distillation.

3. The process according to claim 1 wherein the further step (c) comprises the steps of
(c.1) simultaneously removing the solvent S1 from the reaction mixture as an azeotrope formed by the inert organic solvent S2 and the solvent S1, and
(c.2) adding the inert organic solvent S2 or a mixture comprising the inert organic solvent S2 and having a lower concentration of the solvent S1 as compared to the azeotrope to the reaction mixture during the reaction.

4. The process according to claim 1 wherein, in the further step (c), the solvent S1 is simultaneously and continuously removed from the reaction mixture.

5. The process according to claim 1 wherein the base of the formula (III) is selected from the group consisting of sodium hydroxide, potassium hydroxide, and combinations thereof.

6. The process according to claim 1 wherein the base of the formula (III) is sodium hydroxide.

7. The process according to claim 1 wherein X is selected from halogen, an oxygen linked leaving group, and an ammonium group of the formula (VI)
—N(R 1 )(R 2 )(R 3 ) + Y −   (VI)

wherein R 1 , R 2 and R 3 are each independently selected from C 1 -C 6 -alkyl, C 3 -C 10 -cycloalkyl and C 6 -C 20 -aryl, and Y − is selected from halide, hydroxide, C 1 -C 4 -alkyl sulfonate and C 6 -C 20 -aryl sulfonate ions.

8. The process according to claim 1 wherein X is selected from halogen.

9. The process according to claim 1 wherein the inert organic solvent S2 is capable of forming an azeotrope with water.

10. The process according to claim 1 wherein the inert organic solvent S2 is selected from alkylbenzenes which are mono-, di-, or trialkylsubstituted with each alkyl group containing 1 to 3 carbon atoms.

11. The process according to claim 1 wherein the inert organic solvent S2 is toluene.

12. The process according to claim 1 wherein the 2-Methylbenzyl compound of the formula (V) is 2-Methylbenzyl chloride of the formula (Va)

13. A method for reducing the formation of deposits on the interior of a reactor in which the preparation of (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I)

any one of its individual enantiomers or any non-racemic mixture thereof is conducted by benzylating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II)

any one of its individual enantiomers or any non-racemic mixture thereof with a 2-methylbenzyl compound of the formula (V)

wherein X is a leaving group, said method comprising the steps of
(a) deprotonating (±)-2-exo-hydroxy-l-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), any one of its individual enantiomers or any non-racemic mixture thereof in the presence of at least one base of the formula [M m+ ] n [A n− ] m (III) wherein M m+ represents a m-valent metal cation which is an alkali metal cation wherein m is 1, and A n− represents a n-valent anion which is hydroxide wherein n is 1, said base being capable of forming a solvent S1 which is water under the reaction conditions, to form a metal alkoxide or metal alkoxide solvate of the formula (IV)

any one of its individual enantiomers or any non-racemic mixture thereof wherein M m+ , m and the solvent S1 have the same meaning as defined for the base of formula (III), and x denotes a number from 0 to 10, and
(b) reacting the metal alkoxide or metal alkoxide solvate of the formula (IV), any of its individual enantiomers or any non-racemic mixture thereof with the 2-Methylbenzyl compound of the formula (V)
wherein the steps (a) and (b) are conducted in the presence of at least one inert organic solvent S2 selected from aromatic hydrocarbons and comprise a further step of (c) simultaneously removing the solvent S1 from the reaction mixture.

Assignees

• Basf Agro Bv

Inventors

• Benson Stefan
• Rack Michael
• Goetz Roland
• Wolf Bernd
• Gebhardt Joachim
• Kraus Helmut

Classifications

• C07D493/08 Primary

  Bridged systems · CPC title