Heteroaromatic compounds as BTK inhibitors
US-9975882-B2 · May 22, 2018 · US
US10875852B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10875852-B2 |
| Application number | US-201816160048-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 15, 2018 |
| Priority date | Aug 10, 2012 |
| Publication date | Dec 29, 2020 |
| Grant date | Dec 29, 2020 |
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The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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The invention claimed is: 1. A compound selected from the group consisting of: 2. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 3. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 4. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 5. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 6. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 7. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 8. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 9. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 10. The compound according to claim 1 of formula: or a pharmaceutically acceptable salt thereof. 11. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof. 12. A method of treating a disease chosen from rheumatoid arthritis, systemic lupus erythromatosis, scleroderma, asthma, allergic rhinitis, allergic eczema, B cell lymphoma, multiple sclerosis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, graft versus host disease, psoriatic arthritis, ankylosing spondylitis and uveitis, comprising administering to a patient a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.
directly linked by a ring-member-to-ring-member bond · CPC title
linked by a carbon chain containing alicyclic rings · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
containing three or more hetero rings · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
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