Stepwise method of producing various types of cells from pluripotent stem cells
US-2021363485-A1 · Nov 25, 2021 · US
Intervention for tendinopathy
US10874748B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10874748-B2 |
| Application number | US-201615577470-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 10, 2016 |
| Priority date | Jun 11, 2015 |
| Publication date | Dec 29, 2020 |
| Grant date | Dec 29, 2020 |
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- Title
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Abstract
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Methods for treating tendinopathy and tendonitis and for preventing tendinopathy are disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating a tendinopathy in a subject comprising administering to the subject tendon stem/progenitor cells (TSPCs) transduced or transfected with a vector comprising CREB-binding protein/p300-interacting protein 2 (CITED2) cDNA, wherein the TSPCs are administered to the site of the tendinopathy in an amount effective to treat the tendinopathy in the subject, and wherein the subject does not have a ruptured tendon. 2. The method of claim 1 , wherein the TSPCs have been obtained from a human prior to their transduction or transfection. 3. The method of claim 1 , wherein the TSPCs have been obtained from a human biceps brachii tendon. 4. The method of claim 1 , wherein the tendinopathy is of an Achilles tendon, a knee tendon or an arm tendon. 5. The method of claim 1 , wherein the tendinopathy comprises a tendinosis or a tendonitis. 6. The method of claim 1 , wherein the subject is a human.
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Inventors
Classifications
Purification or manufacturing processes for gene therapy compositions · CPC title
Cells for production · CPC title
- C12N5/066Primary
Tenocytes; Tendons, Ligaments · CPC title
Transcription factors · CPC title
- A61K48/00Primary
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy · CPC title
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Frequently asked questions
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- What does patent US10874748B2 cover?
- Methods for treating tendinopathy and tendonitis and for preventing tendinopathy are disclosed.
- Who is the assignee on this patent?
- Albert Einstein College Medicine, Icahn School Med Mount Sinai, Montefiore Med Center
- What technology area does this patent fall under?
- Primary CPC classification C12N5/066. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).