Implantable medical devices having controlled surface properties for improved healing response

Patent metadata

Field	Value
Publication number	US-10874532-B2
Application number	US-201715608337-A
Country	US
Kind code	B2
Filing date	May 30, 2017
Priority date	Nov 19, 1999
Publication date	Dec 29, 2020
Grant date	Dec 29, 2020

Abstract

An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent.

First claim

What is claimed is:

1. An implantable medical device comprising a biomaterial, the implantable medical device having a biomaterial surface which contacts body tissue or body fluids upon implantation into a body, the biomaterial having a material morphology configured such that the biomaterial surface has a non-random distribution, of a plurality of endothelial cellular attachment sites defined by at least one of grain size, grain phase or grain composition in the material morphology of the biomaterial, wherein the non-random distribution of a plurality of endothelial cellular attachment sites have a repeating pattern of no less than a 1 μm radius and 2 μm border-to-border spacing between endothelial cellular attachment sites.

2. The implantable medical device according to claim 1 , wherein the endothelial cellular attachment sites define polar and non-polar binding sites.

3. The implantable medical device according to claim 1 , wherein the endothelial cellular attachment sites are dimensioned to have a blood contact surface area substantially similar in size as endothelial cell surface integrin clusters.

4. The implantable medical device according to claim 1 , wherein the endothelial cellular attachment sites have a surface area less than a surface area of a human endothelial cell.

5. The implantable medical device according to claim 1 , wherein the endothelial cellular attachment sites are dimensioned to have a blood contact surface area of about less than 6 μm 2 .

6. The implantable medical device according to claim 1 , wherein each of the plurality of the endothelial cellular attachment sites has a blood contact surface less than or equal to about 10 μm.

7. The implantable medical device according to claim 1 , wherein the implantable medical device is a generally tubular structure and the biomaterial surface is at least one of a luminal or abluminal surface of the generally tubular structure.

8. The implantable medical device according to claim 7 , wherein the generally tubular structure further comprises a stent.

Assignees

• Vactronix Scientific Llc

Inventors

• Palmaz Julio C
• Sprague Eugene A

Classifications

• A61F2002/072

  Encapsulated stents, e.g. wire or whole stent embedded in lining · CPC title

• A61F2002/9155

  Adjacent bands being connected to each other · CPC title

• A61F2/82 Primary

  Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) · CPC title

• Y10T29/49936

  Surface interlocking · CPC title

• A61F2220/0058

  soldered or brazed or welded · CPC title