Antibacterial composition comprising an acetal or a long-chain alkyl hexitane ether

Patent metadata

Field	Value
Publication number	US-10874103-B2
Application number	US-201515537871-A
Country	US
Kind code	B2
Filing date	Dec 17, 2015
Priority date	Dec 17, 2014
Publication date	Dec 29, 2020
Grant date	Dec 29, 2020

Abstract

A bactericidal or bacteriostatic composition comprising an acetal or a hexitan ether preferentially of a long-chain alkyl sorbitan, arlitan or mannitan, its use in the treatment or prevention of Gram-positive bacterial infections, its use as a hygiene or dermatological product for external use and a method for disinfecting surfaces.

First claim

The invention claimed is:

1. A method for disinfection or prevention of bacterial colonization by Gram-positive bacteria of a substrate comprising putting the substrate into contact with a bactericidal or bacteriostatic composition comprising a mixture of regioisomers of an alkyl acetal or an alkyl ether of sorbitan, arlitan, mannitan or a pharmaceutically acceptable salt thereof, wherein the alkyl group comprises between 11 to 18 carbon atoms, wherein said alkyl acetal group is in the 2,3-O—; 3,5-O- and/or 5,6-O- positions or said alkyl ether group is in the 2-O, 3-O-, 5-O- and/or 6-O- positions.

2. The method as claimed in claim 1 characterized in that the alkyl group comprises 11 to 13 carbon atoms.

3. The method as claimed in claim 1 characterized in that the Gram-positive bacteria are bacteria from the phylum of Firmicutes, typically of the class of Bacilli in particular chosen from bacteria of the order of Lactobacillales or Bacillales.

4. The method as claimed in claim 3 characterized in that the Gram-positive bacteria are bacteria from the order of Bacillales chosen from the family of Alicyclobacillaceae, Bacillaceae, Caryophanaceae, Listeriaceae, Paenibacillaceae, Pasteuriaceae, Planococcaceae, Sporolactobacillaceae, Staphylococcaceae, Thermoactinomycetacea and Turicibacteriaceae.

5. The method as claimed in claim 3 characterized in that the Gram-positive bacteria are bacteria from the family of Listeriaceae such as a bacterium of the genus Brochothrix or Listeria typically chosen from L. fleischmannii, L. grayi, L. innocua, L. ivanovii, L. marihii, L. monocytogenes, L. rocourtiae, L. seeligeri, L. weihenslephanensis and L. welshimeri.

6. The method as claimed in claim 3 characterized in that the Gram-positive bacteria are bacteria from the family of Staphylococcaceae chosen from bacteria from the genus Staphylococcus, Gemella, Jeolgalicoccus, Macrococcus, Salinicoccus and Nosocomiicoccus.

7. The method as claimed in claim 6 characterized in that the Gram-positive bacteria are bacteria from the genus Staphylococcus chosen from S. arlettae, S. agnelis, S. aureus, S. auricularis, S. capitis, S. caprae, S. carnosus, S. caseolyticus, S. chromogenes, S. cohnii, S. condimenti, S. delphini, S. devriesei, S. epidermidis, S. equorum, S. felis, S. fleurettii, S. gallinarum, S. haemolyticus, S. hominis, S. hyicus, S. intermedius, S. kloosii, S. leei, S. lentus, S. lugdunensis, S. lutrae, S. massiliensis, S. microti, S. muscae, S. nepalensis, S. pasteuri, S. pettenkoferi, S. piscifermentans, S. pseudintermedius, S. pseudolugdunensis, S. pulvereri, S. rostri, S. saccharolyticus, S. saprophyticus, S. schleiferi, S. sciuri, S. simiae, S. simulans, S. stepanovicii, S. succinus, S. vitulinus, S. warneri and S. xylosus.

8. The method as claimed in claim 3 characterized in that the Gram-positive bacteria are Lactobacillales chosen from a family of Aerococcaceae, Carnobacteriaceae, Enterococcaceae, Lactobacillaceae, Leuconostocaceae and Streptococcaceae.

9. The method as claimed in claim 8 characterized in that the Gram-positive bacteria are bacteria from the family of Enterococcaceae chosen from bacteria from the genus Bavariicoccus, Catellicoccus, Enterococcus, Melissococcus, Pilibacler, Tetragenococcus, Vagococcus.

10. The method as claimed in claim 9 characterized in that the Gram-positive bacteria are bacteria from the genus Enterococcus chosen from E. malodoratus, E. avium, E. durans, E. faecalis, E. faecium, E. gallinarum, E. hirae , and E. solitarius.

11. The method as claimed in claim 1 characterized in that the bactericidal or bacteriostatic composition is incorporated in a food, cosmetic, pharmaceutical, phytosanitary, veterinary or surface treatment composition.

12. The method as claimed in claim 1 wherein the method is used externaly for a dermatological product for external purpose.

13. The method as claimed in claim 1 wherein the method is for cleaning, sterilizing or purifying said substrate.

14. The method as claimed in claim 1 wherein the method is for the treatment or prevention of bacterial infections by Gram-positive bacteria and wherein the bactericidal or bacteriostatic composition is administered topically to a subject in need thereof.

15. The method as claimed in claim 14 in which the infection by Gram-positive bacteria is an infection of the skin or mucous membranes, wherein the infection is chosen from folliculitis, an abcess, paronychia, a boil, impetigo, an infection between the digits, anthrax (staphylococcal anthrax), cellulitis, a secondary wound infection, otitis, sinusitis, hidradenitis, infectious mastitis, a post-traumatic skin infection or an infection on burnt skin.

16. The method as claimed in claim 9 characterized in that the Gram-positive bacteria are bacteria from the genus Enterococcus chosen from E. avium, E. durans, E. faecalis and E. faecium.

Assignees

• Tereos Starch & Sweeteners Belgium
• Univ Claude Bernard Lyon
• Centre Nat Rech Scient

Inventors

• Gozlan Charlotte
• Belmessieri Dorine
• Duclos Marie-Christine
• Duguet Nicolas
• Lemaire Marc
• Lina Gérard
• Dumitrescu Oana
• Redl Andreas

Classifications

• A23B2/729

  Organic compounds; Microorganisms; Enzymes · CPC title

• A23B2/771

  Organic compounds containing hetero rings · CPC title

• A23B2/742

  Organic compounds containing oxygen · CPC title

• C11D3/43

  Solvents · CPC title

• A61Q17/005

  Antimicrobial preparations · CPC title