Syringe systems, piston seal systems, stopper systems, and methods of use and assembly

Patent metadata

Field	Value
Publication number	US-10869966-B2
Application number	US-201615048366-A
Country	US
Kind code	B2
Filing date	Feb 19, 2016
Priority date	Feb 20, 2015
Publication date	Dec 22, 2020
Grant date	Dec 22, 2020

Abstract

A syringe system, piston seal systems, stopper systems, and methods for assembling and using the syringe systems. The piston seal system including a piston seal member and a piston head member. The injection system including a container, a piston seal system positioned within the container, and a stopper system coupled to an end of the container. The method of assembling an injection system, the method includes obtaining a container, a piston seal system, and a stopper system. The method also includes inserting the piston seal system into a cavity within the container. The method further includes securing the stopper system at an end of the container in an opening of the cavity. Methods of using the syringe system, piston seal systems, and stopper systems are also disclosed.

First claim

Having thus described the preferred embodiments, the invention is now claimed to be:

1. An injection device, comprising:
a container having a first end and a second end;
a piston configured to move toward the second end of the container;
a seal disposed between the first end of the container and the piston, the seal being spaced apart from and coupled to the piston such that movement of the seal and the piston occur simultaneously, wherein an outer surface of the piston and an outer surface of the seal are configured to engage an interior surface of the container; and
a pressure delivery device configured to convey a first fluid, from exterior of the container, into the container and into contact with the seal to urge initial movement of the seal and the piston from a resting position toward the second end of the container;
wherein a second fluid is configured to be disposed in the container and in direct contact with the piston, wherein movement of the seal and the piston toward the second end of the container urges the second fluid out of the container, and further including a stopper configured to seal the first end of the container.

2. The injection device of claim 1 , further including a needle coupled to the second end of the container.

3. The injection device of claim 1 , further including a stopper configured to seal the first end of the container, wherein the piston is configured to move relative to the stopper.

4. The injection device of claim 3 , wherein the pressure delivery device is configured to convey the first fluid through the stopper into the container.

5. The injection device of claim 1 , wherein the first fluid is pressurized before delivery into the container.

6. The injection device of claim 1 , wherein the piston includes a circumferential ring configured to seal against an inner surface of the container.

7. The injection device of claim 1 , wherein the seal is coupled to the piston by a shaft.

8. The injection device of claim 7 , wherein a diameter of the shaft is less than the outer diameter of the piston, and also is less than the outer diameter of the seal.

9. The injection device of claim 8 , wherein a space between the seal and the piston is configured to contain any first fluid that leaks distally of the seal.

10. The injection device of claim 7 , wherein the shaft is configured to prevent angular shift or tilting of the seal when the pressure delivery device conveys the first fluid into the container.

11. The injection device of claim 1 , wherein the seal includes a circumferential ring configured to seal against an inner surface of the container.

12. The injection device of claim 1 , wherein at least a portion of the stopper is disposed exterior of the container.

13. The injection device of claim 1 , wherein at least a portion of the stopper is disposed within the container.

14. The injection device of claim 1 , wherein the stopper is secured to the first end of the container.

15. An injection device, comprising:
a container having a first end and a second end;
a piston configured to move toward the second end of the container;
a seal disposed between the first end of the container and the piston, the seal being longitudinally spaced apart from the piston, wherein an outer surface of the piston and an outer surface of the seal are configured to engage an interior surface of the container;
a second fluid disposed between the piston and the second end of the container, wherein the piston directly contacts the second fluid; and
a pressure delivery device configured to convey a pressurized first fluid from exterior of the container, into the container and into contact with the seal to urge the seal and the piston toward the second end of the container to advance the second fluid out of the second end of the container, wherein a space between the piston and the seal is configured to trap any second fluid that leaks proximally past the piston, and trap any pressurized first fluid that leaks distally past the seal, wherein the first fluid is a gas that drives initial movement of the seal.

16. The injection device of claim 15 , wherein the seal and the piston each includes a plurality of longitudinally spaced apart circumferential rings that are configured to seal against an inner surface of the container.

17. An injection device, comprising:
a container having a first end and a second end;
a piston configured to move toward the second end of the container;
a seal disposed between the first end of the container and the piston, the seal being spaced apart from and coupled to the piston such that movement of the seal and the piston occur simultaneously, wherein an outer surface of the piston and an outer surface of the seal are configured to engage an interior surface of the container;
a pressure delivery device configured to convey a first fluid, from exterior of the container, into the container and into contact with the seal to urge initial movement of the seal and the piston from a resting position toward the second end of the container; and
a stopper configured to seal the first end of the container, wherein the piston is configured to move relative to the stopper;
wherein a second fluid is configured to be disposed in the container between the piston and the second end of the container such that:
the piston is configured to directly contact the second fluid; and
movement of the seal and the piston toward the second end of the container is configured to urge the second fluid out of a distalmost portion of the container.

18. The injection device of claim 17 , further including a needle coupled to the second end of the container.

19. The injection device of claim 17 , wherein the pressure delivery device is configured to convey the first fluid through the stopper into the container.

20. The injection device of claim 17 , wherein the first fluid is pressurized before delivery into the container.

21. The injection device of claim 17 , wherein the first fluid is a gas.

Assignees

• Regeneron Pharma

Inventors

• Cupicha Michael
• Goraltchouk Alexei
• Hart Ian
• Stelmah Mike

Classifications

• F16J9/20

  Rings with special cross-section (L-section rings F16J9/02); Oil-scraping rings {(F16J9/06 takes precedence)} · CPC title

• F16J1/005

  obtained by assembling several pieces · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title

• A61M2005/31523

  for reducing reflux · CPC title

• A61M2005/3131

  specially adapted for improving sealing or sliding · CPC title