Progressive cellular architecture for microfabricated gas chromatograph

Patent metadata

Field	Value
Publication number	US-10866220-B2
Application number	US-201815978744-A
Country	US
Kind code	B2
Filing date	May 14, 2018
Priority date	May 15, 2017
Publication date	Dec 15, 2020
Grant date	Dec 15, 2020

Abstract

In order to achieve a system capable of analyzing a wide range of compounds while saving time and energy consumption, a progressive cellular architecture is presented for vapor collection and gas chromatographic separation. Each cell includes a preconcentrator and separation column that are adapted for collecting and separating compounds only within a specific volatility range. A wide volatility range can therefore be covered by the use of multiple cells that are cascaded in the appropriate order. The separation columns within each cell are short enough to reduce the heating and pumping requirements. The gas flow for vapor collection and separation is provided by low-power gas micropumps that use ambient air. The system is also configurable to incorporate capabilities of detecting and reducing vapor overload. The progressive cellular architecture directly address the compromise between low power and broad chemical analyses.

First claim

What is claimed is:

1. A gas chromatography architecture, comprising:
two or more preconcentrators coupled together in series, the two or more preconcentrators having an input configured to receive an analyte and an output, each preconcentrator comprising a chamber through which the analyte passes and sorbent material within the chamber, wherein surface area of sorbent material residing in a given preconcentrator increases from the input to the output across the two or more preconcentrators;
a separation column associated with each preconcentrator of the two or more preconcentrators, each separation column having a channel through which the analyte passes; and
a three-port fluidic coupling device disposed at an inlet of each preconcentrator in the two or more preconcentrators, the first port of the fluidic coupling device configured to receive an incoming analyte, the second port of the fluidic coupling device fluidly coupled to an inlet of an associated preconcentrator and a third port of the fluidic coupling device fluidly coupled to an associated separation column.

2. The gas chromatography architecture of claim 1 further comprises a pump fluidly coupled to the output of the two or more preconcentrators.

3. The gas chromatography architecture of claim 2 wherein the pump operates to draw the analyte in a first direction during the collection phase and operates to drive a carrier gas in a second direction opposite the first direction during a separation phase.

4. The gas chromatography architecture of claim 1 further comprises a detector selectively coupled to each of the separation columns, each separation column having an outlet fluidly coupled along a separation path to the detector.

5. The gas chromatography architecture of claim 4 further comprising a secondary detector disposed upstream from one of the two or more preconcentrators, wherein the controller is in data communication with the secondary detector and, in response to detecting a vapor concentration above a threshold, operates to reduce flow rate of the pump or reduce the collection period during the collection phase.

6. The gas chromatography architecture of claim 4 further comprising
a secondary detector disposed along a given separation path downstream from a given separation column;
a secondary separation column disposed downstream along the given separation path from the secondary detector; and
a secondary three-port fluidic coupling device fluidly coupled between the secondary detector and the secondary separation column.

7. The gas chromatography architecture of claim 1 wherein the analyte traverses the two or more preconcentrators in a first direction during a collection phase and a carrier gas that traverses the preconcentrators in a second direction during a separation phase.

8. The gas chromatography architecture of claim 1 wherein each separation column includes a stationary phase and the stationary phases vary amongst the separation columns.

9. The gas chromatography architecture of claim 1 wherein each of the three-port fluidic coupling device is configured in a normally open position whereby the first port is fluidly coupled to the second port while gas flow through the third port is blocked.

10. The gas chromatography architecture of claim 9 further comprises a controller operably coupled to each of the fluidic coupling devices, wherein the controller maintains each of the fluidic coupling devices in the normally open position during a collection phase.

11. The gas chromatography architecture of claim 10 wherein the controller actuates each of the fluidic coupling devices in succession from a normally open position to a closed position during a separation phase, whereby the second port is fluidly coupled to the third port while the first port is blocked in the closed position.

12. The gas chromatography architecture of claim 1 further comprises:
a polar separation column disposed downstream along a given separation path from a given three-port fluidic coupling device; and
a non-polar separation column disposed downstream in the given separation path from the given three-port fluidic coupling device and arranged in parallel with the polar separation column.

13. A method for gas chromatography, comprising:
providing two or more preconcentrators coupled together in series, each preconcentrator comprising a chamber through which the analyte passes and having sorbent material within the chamber,
drawing a carrier gas with an analyte in a first direction through an inlet and into the two or more preconcentrators during a collection phase, where surface area of sorbent material in a given preconcentrator increases across the two or more preconcentrators in the first direction;
associating a separation column with each preconcentrator in the two or more preconcentrators, each separation column having a channel through which the analyte passes;
driving the carrier gas in a second direction through the two or more preconcentrators during a separation phase, where the second direction is opposite the first direction; and
directing the carrier gas through the separation columns successively, such that the carrier gas passes through a given separation column while blocking the carrier gas from entering preconcentrators located downstream of the given separation column.

14. The method of claim 13 further comprises detecting vapor concentration at output of the separation columns.

15. The method of claim 13 further comprises disposing a three-port fluidic coupling device at an inlet of each preconcentrator in the two or more preconcentrators, the first port of the fluidic coupling device configured to receive an incoming carrier gas, the second port of the fluidic coupling device fluidly coupled to an inlet of an associated preconcentrator and the third port of the fluidic coupling device fluidly coupled to an associated separation column.

16. The method of claim 15 further comprises controlling each of the fluidic coupling devices using a controller, wherein each of the three-port fluidic coupling device is configured in a normally open position whereby the first port is fluidly coupled to the second port while gas flow through the third port is blocked, and the controller maintains each of the fluidic coupling devices in the normally open position during the collection phase.

17. The method of claim 16 further comprises actuating each of the fluidic coupling devices in succession from a normally open position to a closed position during the separation phase, whereby the second port is fluidly coupled to the third port while the first port is blocked in the closed position.

Assignees

• Univ Michigan Regents

Inventors

• Gianchandani Yogesh B
• Qin Yutao

Classifications

• G01N2030/085

  using absorbing precolumn · CPC title

• G01N30/08 Primary

  using an enricher · CPC title

• G01N30/78

  using more than one detector · CPC title

• G01N30/6095 Primary

  Micromachined or nanomachined, e.g. micro- or nanosize · CPC title

• G01N2030/025

  Gas chromatography · CPC title