Gripping fabric coated with a bioresorbable impenetrable layer

Patent metadata

Field	Value
Publication number	US-10865505-B2
Application number	US-201013393994-A
Country	US
Kind code	B2
Filing date	Sep 6, 2010
Priority date	Sep 4, 2009
Publication date	Dec 15, 2020
Grant date	Dec 15, 2020

Abstract

The present invention relates to a prosthetic fabric (5) comprising an arrangement (2) of yarns that define at least first and second opposite faces (2a, 2b) for said fabric, said fabric comprising on at least said first face, one or more barbs (3) that protrude outwards relative to said first face, said fabric being covered, at least partly, on said second face with a microporous layer made of a bioresorbable material, said barbs being covered with a coating made of a water-soluble material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric.

First claim

What is claimed is:

1. A prosthetic fabric comprising:
an arrangement of yarns that define at least first and second opposite faces for the fabric, the fabric comprising on at least the first face one or more barbs that protrude outwards from the first face, the fabric being covered, at least partly, on the second face with a microporous film layer including pores which promote cell colonization therein and made of a bioresorbable material, an outer surface of the layer being impenetrable by the barbs, the fabric having a delivery configuration for laparoscopic surgery in which the fabric is rolled upon itself to form an overlapped portion of the fabric in which the barbs contact the layer of the bioresorbable material and are stopped from engaging the overlapped portion of the fabric by the outer surface of the layer of the bioresorbable material so that the barbs do not enter the layer, wherein the barbs are covered with a coating made of a water-soluble material, and the barbs including the coating are configured to slide over one another when rolled, wherein the water-soluble material is selected from the group consisting of polyethylene glycols, polyvinyl acetates, gelatin, polyglucuronic acid, hyaluronic acid, carboxymethyl cellulose, cellulose ethers, chitosan and mixtures thereof.

2. The fabric according to claim 1 , wherein the outer surface of the layer is impenetrable by the barbs is continuous and completely covers the second face.

3. The fabric according to claim 1 , wherein the bioresorbable material is selected from the group consisting of collagen compounds, hydrophilic macromolecular compounds, polyvinyl alcohols, glycerols, and mixtures thereof.

4. The fabric according to claim 3 , wherein the bioresorbable material comprises at least one collagen compound.

5. The fabric according to claim 4 , wherein the collagen compound comprises oxidized collagen.

6. The fabric according to claim 4 , wherein the collagen compound comprises gelatin.

7. The fabric according to claim 3 , wherein the hydrophilic macromolecular compounds are selected from the group consisting of polyalkylene glycols, such as polyethylene glycol or polypropylene glycol, polysaccharides, such as starch, dextran and/or derivatives of cellulose, oxidized polysaccharides, mucopolysaccharides, and mixtures thereof.

8. The fabric according to claim 7 , wherein the hydrophilic macromolecular compound is a polyethylene glycol having a molar mass of 4000 daltons.

9. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one glycerol.

10. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one collagen compound and at least one glycerol.

11. The fabric according to claim 10 , wherein the bioresorbable material comprises at least one hydrophilic macromolecular compound.

12. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one polyvinyl alcohol.

13. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one polyvinyl alcohol and at least one glycerol.

14. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one collagen compound and at least one polyvinyl alcohol.

15. The fabric according to claim 1 , wherein the bioresorbable material comprises at least one bioactive agent.

16. The fabric according to claim 1 , wherein the water-soluble material comprises at least one bioactive agent.

17. A prosthesis for the treatment of hernias manufactured from a fabric according to claim 1 .

18. The fabric according to claim 1 , wherein only the barbs are covered with the coating made of the water-soluble material.

19. The fabric according to claim 1 , wherein the microporous layer includes pores from 20 to 150 μm.

20. The fabric according to claim 1 , wherein the bioresorbable material is water soluble at 37° C. and not water soluble at 25° C.

21. The fabric according to claim 1 , wherein the microporous layer is the outermost layer of the second face.

22. The fabric according to claim 19 , wherein the pores are in a surface and a thickness of the microporous layer.

23. The fabric according to claim 1 , wherein the barbs including the coating are further configured to slide over tissue when implanted.

24. The fabric according to claim 23 , wherein the barbs are configured to fasten to tissue when the coating is removed from the barbs following implantation.

25. The fabric according to claim 1 , wherein at least one of the yarns of the arrangement of yarns forms the barbs.

26. The fabric according to claim 25 , wherein the at least one yarn of the arrangement of yarns that forms the barbs is a hot-melt monofilament yarn.

27. A prosthetic fabric comprising:
an arrangement of yarns that define at least first and second opposite faces for the fabric, the fabric comprising on at least the first face one or more barbs that protrude outwards from the first face, the fabric being covered, at least partly, on the second face with a microporous film layer including pores which promote cell colonization therein and made of a bioresorbable material, an outer surface of the layer being impenetrable by the barbs, the fabric having a delivery configuration for laparoscopic surgery in which the fabric is rolled upon itself to form an overlapped portion of the fabric in which the barbs contact the layer of the bioresorbable material and are stopped from engaging the overlapped portion of the fabric by the outer surface of the layer of the bioresorbable material so that the barbs do not enter the layer, wherein the barbs are covered with a coating made of a water-soluble material, and the barbs including the coating are configured to slide over one another when rolled and slide over tissue when implanted.

Assignees

• Montanari Suzelei
• Bayon Yves
• Bourges Xavier
• Petit Delphine
• Sofradim Production

Inventors

• Montanari Suzelei
• Bayon Yves
• Bourges Xavier
• Petit Delphine

Classifications

• D10B2501/0632

  of the touch-and-close type · CPC title

• D04B21/12 Primary

  characterised by thread material · CPC title

• A61L2300/61

  containing two or more active agents in different layers · CPC title

• D10B2403/0112

  One smooth surface, e.g. laminated or coated · CPC title

• D10B2509/08

  Hernia repair mesh · CPC title