Process for extracting materials from biological material

Patent metadata

Field	Value
Publication number	US-10865334-B2
Application number	US-201414451845-A
Country	US
Kind code	B2
Filing date	Aug 5, 2014
Priority date	Jun 7, 2010
Publication date	Dec 15, 2020
Grant date	Dec 15, 2020

Abstract

The invention is directed to a process for extracting materials from biological material, which process is characterized in that the naturally occurring biological material is treated with an extractant consisting of a deep eutectic solvent of natural origin or a an ionic liquid of natural origin to produce a biological extract of natural origin dissolved in the said solvent or ionic liquid.

First claim

The invention claimed is:

1. A process for extracting materials from a biological material, comprising:
treating the biological material with an extractant comprising a deep eutectic solvent to produce a biological extract dissolved in said extractant, wherein the deep eutectic solvent comprises a first component and a second component, wherein the first component consists of at least one naturally occurring organic acid; and wherein the second component is selected from the group consisting of (i) at least one mono- or dimeric sugar or sugar alcohol selected from the group consisting of sucrose, glucose, fructose, lactose, maltose, galactose, raffinose, xylose, mannose, trehalose, sorbitol, erythritol, rhamnose, inositol, xylitol, ribitol, and adonitol, (ii) an amino acid selected from the group consisting of alanine, glutamic acid, glutamate, proline and serine, or (iii) 1,2-propanediol, or wherein the deep eutectic solvent comprises at least two sugars selected from the group consisting of glucose, fructose, sucrose and lactose; or wherein the deep eutectic solvent comprises (i) choline or betaine and (ii) said first component or said second component; and wherein the molar ratio of the components of the deep eutectic solvent is between 1:1 and 5:1; wherein the biological extract comprises a flavonoid or an anthocyanin; and wherein said biological material originates from a source selected from the group consisting of plants, insects, animals, and micro-organisms.

2. The process of claim 1 , wherein the said naturally occurring organic acid is selected from the group consisting of: malic acid, maleic acid, citric acid, lactic acid, pyruvic acid, fumaric acid, succinic acid, acetic acid, aconitic acid, tartaric acid, ascorbic acid, malonic acid, oxalic acid, glucuronic acid, neuraminic acid and sialic acids.

3. The process of claim 1 , wherein the deep eutectic solvent further comprises water.

4. The process of claim 1 , wherein the deep eutectic solvent has a melting point below 25° C.

5. The process of claim 1 , wherein the biological extract is recovered from said deep eutectic solvent.

6. The process of claim 1 , wherein the deep eutectic solvent is selected from the group consisting of malic acid:β-alanine:water (1:1:3), proline:malic acid:water (1:1:3), fructose:glucose:sucrose:water (1:1:1:11), fructose:glucose:malic acid (1:1:1) and lactose:glucose:water (5:1:2).

7. The process of claim 1 , wherein the flavonoid is rutin, quercetin or quercitrin.

8. A process for extracting materials from a biological material, comprising:
treating the biological material with an extractant consisting of a deep eutectic solvent to produce a biological extract dissolved in said extractant, wherein the deep eutectic solvent comprises (i) alanine and malic acid, (ii) fructose and sucrose, (iii) fructose and glucose, (iv) proline and sucrose, (v) malic acid and glucose, (vi) malic acid and sucrose, (vii) citric acid and sucrose, (viii) lactose and glucose or (ix) glucose and; wherein the molar ratio of the components of the deep eutectic solvent is between 1:1 and 5:1; wherein the biological extract comprises galanthamine or paclitaxel; and wherein said biological material originates from a source selected from the group consisting of plants, insects, animals and micro-organisms.

Assignees

• Univ Leiden

Inventors

• Van Spronsen Jacob
• Witkamp Geert-Jan
• Hollman Frank
• Choi Young Hae
• Verpoorte Robert

Classifications

• B01D11/0288 Primary

  Applications, solvents · CPC title

• C07D311/62

  with oxygen atoms directly attached in position 3, e.g. anthocyanidins · CPC title

• C09K3/00 Primary

  Materials not provided for elsewhere · CPC title

• B01D11/04

  of solutions which are liquid · CPC title

• C07H17/07

  Benzo[b]pyran-4-ones · CPC title