Fabricating a carbon nanofiber yarn nerve scaffold

Patent metadata

Field	Value
Publication number	US-10864301-B2
Application number	US-201916353608-A
Country	US
Kind code	B2
Filing date	Mar 14, 2019
Priority date	Mar 15, 2018
Publication date	Dec 15, 2020
Grant date	Dec 15, 2020

Abstract

Nerve scaffolds are described that include a tubular outer housing fabricated from a biocompatible polymer, within which are disposed a plurality of carbon nanofiber yarns. The carbon nanofiber yarns, which can be separated by distances roughly corresponding to an average nerve fiber diameter, provide surfaces on which nerve fibers can regrow. Because the proximate carbon nanofiber yarns can support individual nerve fibers, a nerve can be regenerated with a reduced likelihood of undesirable outcomes, such as nerve pain or reduced nerve function.

First claim

What is claimed is:

1. A method of manufacturing a nerve scaffold, the method comprising:
disposing a first strip of adhesive on a roller;
wrapping a nanofiber yarn around the roller by rotating the roller, the wrapped nanofiber yarn forming a bundle of aligned segments of the nanofiber yarn on the roller, wherein the nanofiber yarn passes over the first strip of adhesive;
separating the bundle of aligned segments of the nanofiber yarn by dividing the strip into two portions;
removing the bundle aligned segments of the nanofiber yarn from the roller;
folding the bundle of aligned segments of the nanofiber yarn, wherein the bundle includes a first end and a second end opposite to the first end; and
configuring the bundle to be disposed within a tube.

2. The method of claim 1 , further comprising disposing a second strip of adhesive on the roller, the first strip of adhesive and the second strip of adhesive defining a gap therebetween.

3. The method of claim 2 , wherein separating the bundle of nanofiber yarn occurs at the gap defined by the first strip of adhesive and the second strip of adhesive.

4. The method of claim 1 , wherein the bundle of aligned segments of the nanofiber yarn includes a midpoint, and wherein the folding comprises folding the bundle of the nanofiber yarn at the midpoint.

5. The method of claim 4 , wherein the midpoint of the folded bundle is connected to a drawing structure, the drawing structure used for placing the folded bundle within the tube.

6. The method of claim 5 , further comprising cutting the first end and second end of the folded bundle of aligned segments of nanofiber yarns.

7. The method of claim 6 , wherein the cutting of the first end and the second end of the bundle of aligned segments of the nanofiber yarn causes the bundle of aligned segments of nanofiber yarns to expand to fill a cross-section of the tube.

8. The method claim 1 , wherein the folded bundle includes from 1000 to 8000 aligned segments of the nanofiber yarn.

9. The method of claim 1 , wherein a weight ratio of the folded bundle of the nanofiber yarn to the tube in which the folded bundle is disposed is about 0.65 to about 1.

10. The method claim 1 , wherein the nanofiber yarn has a diameter of from 5 μm to 30 μm.

11. The method claim 1 , wherein the nanofiber yarn has a diameter of from 13 μm to 15 μm.

12. The method of claim 1 , wherein the nanofiber yarn is comprised of carbon nanotubes.

13. The method of claim 1 , further comprising forming the tube by:
forming a cylindrical helix comprising a surgical suture material, the cylindrical helix defining an interior; and
wrapping a carbon nanofiber sheet around the cylindrical helix on a surface of the helix opposite the interior.

14. The method of claim 1 , wherein the nanofiber yarn is a false twisted nanofiber yarn.

15. The method claim 1 , wherein the nanofiber yarn is a single ply false twisted nanofiber yarn.

16. The method of claim 1 , wherein a surface of the nanofiber yarn has an absence of surface topographic features greater than 1 μm above or below a surface of the nanofiber yarn.

17. The method claim 1 , wherein a surface of the nanofiber yarn has surface topographic features less than 0.1 μm above or below a surface of the nanofiber yarn.

18. The method of claim 1 , wherein the bundle of aligned segments of nanofiber yarn occupies between 1 and 5%, 1 and 10%, 1 and 20%, 1 and 30%, 1 and 40% or 1 and 50% of a volume of the tube in which the bundle is disposed.

19. The method of claim 1 , wherein an average distance between proximate aligned segments of the nanofiber yarn disposed within the tube is from 5 μm to 15 μm.

Assignees

• Lintec America Inc

Inventors

• Bykova Julia
• Lima Marcio D
• Inoue Kanzan

Classifications

• A61B17/1128 Primary

  of nerves · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• D02G1/0206

  by false-twisting · CPC title

• D10B2509/04

  Sutures · CPC title

• D02G3/02

  Yarns or threads characterised by the material or by the materials from which they are made · CPC title