Methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts

Patent metadata

Field	Value
Publication number	US-10856545-B2
Application number	US-201916446762-A
Country	US
Kind code	B2
Filing date	Jun 20, 2019
Priority date	Jun 26, 2009
Publication date	Dec 8, 2020
Grant date	Dec 8, 2020

Abstract

The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

First claim

The invention claimed is:

1. A method of preparing a clean, disinfected autologous tissue implant for implantation, the method comprising:
a) pre-treating autologous tissue surgically removed and collected from a patient;
b) shipping the pre-treated autologous tissue to a tissue processing facility;
c) receiving at the tissue processing facility the pre-treated autologous tissue that has been removed from the patient;
d) processing the pre-treated autologous tissue to clean and disinfect the autologous tissue, wherein the processing comprises treating the autologous tissue with a detergent;
e) storing the processed autologous tissue at an external storage facility; and
f) providing the clean, disinfected autologous tissue to a surgical facility for re-implantation into the patient,
wherein the autologous tissue is a facial bone, a bone of the extremities, a soft tissue, or a periprosthetic bone.

2. The method of claim 1 , wherein the facial bone is mandible bone, frontal bone, parietal bone, spheroid bone, temporal bone or nasal bone.

3. The method of claim 1 , wherein the bone of the extremities is a bone of the hand, a bone of the foot, a bone of the arm, or a bone of the leg.

4. The method of claim 3 , wherein the bone of the leg is a tibial bone or a femoral bone.

5. The method of claim 1 , wherein the soft tissue is at least one of a ligament, a tendon, a fascia, or a muscle.

6. The method of claim 1 , wherein the pre-treating comprises treating the collected autologous tissue with an antibiotic solution, a bactericidal solution, a virucidal, a glycerol-containing solution, water, saline or a combination thereof.

7. The method of claim 1 , wherein the processing comprises debridement.

8. The method of claim 1 , wherein the processing comprises treating the autologous tissue with a plasticizer.

9. The method of claim 1 , wherein the processing comprises exposing the autologous tissue to at least one bioactive factor.

10. The method of claim 1 , wherein the autologous tissue is sterilized using irradiation after processing.

11. The method of claim 1 , further comprising storing the processed autologous tissue in a storage solution.

12. The method claim 11 , wherein the autologous tissue is irradiated while in the storage solution.

Assignees

• Lifenet Health

Inventors

• Bracone Roberto
• Chen Jingsong
• Gatin Marilyn
• Chen Silvia
• Clagett James A
• Osborne Daniel

Classifications

• A01N1/124 Primary

  Disinfecting agents, e.g. antimicrobials · CPC title

• A61F2/2875 Primary

  Skull or cranium (A61F2/2803 takes precedence; joints for temporo-mandibular [TM] joints [TMJ] A61F2/3099) · CPC title

• A61F2/28

  Bones · CPC title

• A61F2310/00359

  Bone or bony tissue · CPC title

• A61F2/4644

  Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material (bone material A61F2/28; disintegrating or milling devices B02C) · CPC title