Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH

Patent metadata

Field	Value
Publication number	US-10849841-B2
Application number	US-201815894691-A
Country	US
Kind code	B2
Filing date	Feb 12, 2018
Priority date	Jun 16, 2006
Publication date	Dec 1, 2020
Grant date	Dec 1, 2020

Abstract

This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

First claim

What is claimed is:

1. A method of treating androgenetic alopecia (AGA) in a scalp of a subject, comprising the step of orally administering to said subject an effective amount of a compound or composition comprising a prostaglandin D2 antagonist, thereby treating an AGA in a scalp of a subject.

2. The method of claim 1 , further comprising the step of administering to said subject a pro-hair growth prostaglandin selected from a prostaglandin E1, a prostaglandin E2, a prostaglandin F2a; or an analogue thereof.

3. A method of treating androgenetic alopecia (AGA) in a scalp of a subject, comprising the step of orally administering to said subject an effective amount of a prostaglandin (PG) D receptor (DP receptor) antagonist, thereby treating an AGA in a scalp of a subject.

4. The method of claim 1 , wherein said compound or composition decreases a level of a prostaglandin D2 in said scalp.

5. The method of claim 1 , wherein the prostaglandin D2 antagonist is a prostaglandin (PG) D receptor (DP receptor) antagonist.

6. The method of claim 5 , wherein the DP receptor antagonist is a CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)/DP2 receptor antagonist.

7. The method of claim 3 , wherein the DP receptor antagonist is a CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)/DP2 receptor antagonist.

Assignees

• Univ Pennsylvania

Inventors

• Cotsarelis George
• Garza Luis

Classifications

• A01K67/0275 Primary

  Genetically modified vertebrates, e.g. transgenic · CPC title

• C12N2830/008

  cell type or tissue specific enhancer/promoter combination · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K8/36

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• C12N15/8509

  for producing genetically modified animals, e.g. transgenic · CPC title