Morbidity diagnosis support system, morbidity diagnosis data-generating system, and morbidity diagnosis support method

Patent metadata

Field	Value
Publication number	US-10846850-B2
Application number	US-201716319836-A
Country	US
Kind code	B2
Filing date	Jul 24, 2017
Priority date	Jul 25, 2016
Publication date	Nov 24, 2020
Grant date	Nov 24, 2020

Abstract

Provided are a morbidity diagnosis support system, a morbidity diagnosis data-generating system, and a morbidity diagnosis support method that are capable of supporting a highly reliable morbidity diagnosis. A morbidity diagnosis support system includes an extension device for extending a tissue section of cells, an image-photographing device for acquiring image data by image-photographing the tissue section, an image analysis device for analyzing the image data to calculate an index of morbidity based on a mode of cracks generated in the tissue section by the extension, and an output device for outputting the calculated index.

First claim

The invention claimed is:

1. A morbidity diagnosis support system comprising:
an extension device for extending a tissue section of cells;
an image-photographing device for acquiring image data by image-photographing the tissue section;
an image analysis device for analyzing the image data to calculate an index of morbidity based on a mode of cracks generated in the tissue section by the extension; and
an output device for outputting the calculated index.

2. The morbidity diagnosis support system according to claim 1 , wherein the extension device extends the tissue section by clipping a stretchable sheet provided with the tissue section and stretching the stretchable sheet.

3. The morbidity diagnosis support system according to claim 2 , wherein the stretchable sheet is formed of polyurethane gel.

4. The morbidity diagnosis support system according to claim 1 , wherein the image analysis device calculates an area of cells contained in the tissue section and an area of cracked part generated in the tissue section, and calculates the index based on the area of cells and the area of cracked part.

5. The morbidity diagnosis support system according to claim 1 , wherein the image analysis device calculates an area of cracked part generated in the tissue section and a length of the cracked part, and calculates the index based on the area and length of cracked part.

6. The morbidity diagnosis support system according to claim 1 , wherein the image analysis device converts at least a part of an image photographed by the image-photographing device into a spatial frequency domain, and calculates the index based on a frequency distribution obtained as a result of conversion into the spatial frequency domain.

7. The morbidity diagnosis support system according to claim 1 , wherein the image analysis device calculates a spatial correlation coefficient representing a feature of a geometric shape of a crack based on a shape of the crack on an image photographed by the image-photographing device, and calculates the index based on the spatial correlation coefficient.

8. A morbidity diagnosis support method comprising:
a tissue section extension step of extending a tissue section of cells;
an image data acquisition step of acquiring image data of the tissue section by an image-photographing device;
an index calculation step of calculating an index of morbidity based on a mode of cracks generated in the tissue section by the extension, by allowing an image analysis device to analyze the image data; and
an index output step of outputting the index by an output device.

9. The morbidity diagnosis support method according to claim 8 , further comprising a prepared slide creation step of creating a prepared slide by providing the tissue section on a stretchable sheet, wherein the tissue section is extended by stretching the stretchable sheet in the tissue section extension step.

10. The morbidity diagnosis support method according to claim 9 , wherein the tissue section is stained in the prepared slide creation step.

11. The morbidity diagnosis support method according to claim 9 , wherein a polyurethane gel sheet is used as the stretchable sheet in the prepared slide creation step.

Assignees

• The Doshisha

Inventors

• Yoshikawa Kenichi
• Ikegawa Masaya
• KENMOTSU Takahiro
• KAKUDA Nobuto
• Nakamura Takuto
• DANNO Keisuke
• OKOSO Natsumi
• Nakamura Naohiko
• IGUCHI Kohta
• Hatano Etsuro
• Uemoto Shinji

Classifications

• G01N33/4833 Primary

  of solid biological material, e.g. tissue samples, cell cultures (tissue in vivo A61B5/00; cell suspensions G01N33/48735) · CPC title

• G01N1/28

  Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title

• G01N33/48

  Biological material, e.g. blood, urine (G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence); Haemocytometers (counting blood corpuscules distributed over a surface by scanning the surface G06M11/02) · CPC title

• G06T7/0012 Primary

  Biomedical image inspection · CPC title

• G06T2207/30024

  Cell structures in vitro; Tissue sections in vitro · CPC title