Method of remediation of organic toxins using supported lipid bilayer nanoparticles

Patent metadata

Field	Value
Publication number	US-10843243-B2
Application number	US-201515123711-A
Country	US
Kind code	B2
Filing date	Mar 6, 2015
Priority date	Mar 7, 2014
Publication date	Nov 24, 2020
Grant date	Nov 24, 2020

Abstract

The present invention relates to methods and compositions for water treatment and environmental remediation using nanoparticle supported lipid bilayers (NP-SLBs). In one embodiment, the NP-SLBs are single or multilayer lipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) supported by silica.

First claim

The invention claimed is:

1. A method of in situ environmental remediation comprising:
contacting contaminated soil or water with a remediation composition, said remediation composition comprising a silica nanoparticle supported phospholipid bilayer (NP-SLB) composition,
wherein the NP-SLB composition is a silica nanoparticle having a single phospholipid bilayer attached thereto;
wherein the NP-SLB composition absorbs one or more hydrophobic organic contaminants from said contaminated soil or water; and
degrading or decomposing the one or more hydrophobic contaminants adsorbed to the NP-SLB composition with a microorganism while maintaining the NP-SLB composition in contact with the soil or water.

2. The method of claim 1 , wherein the NP-SLB composition further comprises a mixture of single lipid bilayer nanoparticles and multiple lipid bilayer nanoparticles.

3. The method of claim 1 , wherein the remediation composition further comprises small unilamellar vesicles (SUVs).

4. The method of claim 3 , wherein at least a portion of the SUVs are attached to an NP-SLB.

5. The method of claim 1 , wherein the remediation composition further comprises large unilamellar vesicles (LUVs).

6. The method of claim 5 , wherein at least a portion of the LUVs are attached to an NP-SLB.

7. The method of claim 1 , wherein the remediation composition further comprises multilamellar vesicles (MLVs).

8. The method of claim 7 , wherein at least a portion of the MLVs are attached to an NP-SLB.

9. The method of claim 1 , wherein the lipid bilayer comprises 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC).

10. The method of claim 1 , wherein the lipid bilayer comprises 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

11. The method of claim 1 , wherein the one or more hydrophobic organic contaminants is a polycyclic aromatic hydrocarbon (PAH).

Assignees

• Univ Temple

Inventors

• Wunder Stephanie L
• Kim Bojeong

Classifications

• C02F1/285 Primary

  using synthetic organic sorbents · CPC title

• C02F2101/327

  Polyaromatic Hydrocarbons [PAH's] · CPC title

• C02F1/281

  using inorganic sorbents · CPC title

• B01J20/22

  comprising organic material · CPC title

• C02F2305/08

  Nanoparticles or nanotubes · CPC title