Chemical compositions with antimicrobial functionality

Patent metadata

Field	Value
Publication number	US-10836864-B2
Application number	US-201715839410-A
Country	US
Kind code	B2
Filing date	Dec 12, 2017
Priority date	Dec 12, 2017
Publication date	Nov 17, 2020
Grant date	Nov 17, 2020

Abstract

Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.

First claim

What is claimed is:

1. A method for inhibiting Mycobacterium tuberculosis , comprising:
contacting a Mycobacterium tuberculosis microbe with a chemical compound, the chemical compound comprising an ionene unit, and the ionene unit comprising a cation distributed along a molecular backbone, wherein the ionene unit has antimicrobial functionality, wherein the molecular backbone is degradable, and wherein the chemical compound is characterized by the following structure:

wherein X is the cation, wherein R is a hydrophobic functional group, wherein n is an integer greater than or equal to two and less than or equal to one thousand, and wherein L is a linkage group selected from the group consisting of an ester group and a carbonyl group; and
electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.

2. The method of claim 1 , wherein the method further comprises:
destabilizing the membrane through integration of the hydrophobic functional group into the membrane.

3. The method of claim 1 , wherein the cation is a nitrogen cation selected from the group comprising a protonated secondary amine cation, a protonated tertiary amine cation, a quaternary ammonium cation and an imidazolium cation.

4. The method of claim 3 , wherein the method further comprises:
destabilizing the membrane through integration of the hydrophobic functional group into the membrane.

5. A method for inhibiting Mycobacterium tuberculosis , comprising:
contacting a Mycobacterium tuberculosis microbe with a chemical compound, the chemical compound comprising an ionene unit, and the ionene unit comprising a cation distributed along a molecular backbone, wherein the ionene unit has antimicrobial functionality, wherein the molecular backbone is degradable, and wherein the chemical compound is characterized by the following structure:

wherein X is the cation, wherein R is a hydrophobic functional group, wherein n is an integer greater than or equal to two and less than or equal to one thousand, and wherein L is a linkage group selected from the group consisting of: an alkyl group, aryl group, an alkenyl group, an aldehyde group, an ester group, a carboxyl group, and a carbonyl group; and
electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.

6. The method of claim 5 , wherein the cation is a nitrogen cation selected from the group comprising a protonated secondary amine cation, a protonated tertiary amine cation, a quaternary ammonium cation and an imidazolium cation.

7. The method of claim 6 , wherein the method further comprises:
destabilizing the membrane through integration of the hydrophobic functional group into the membrane.

8. The method of claim 5 , wherein the ionene unit has a chemical structure selected from the group consisting of:

9. A method for inhibiting Mycobacterium tuberculosis , comprising:
contacting a Mycobacterium tuberculosis microbe with a chemical compound, the chemical compound comprising an ionene unit, and the ionene unit comprising a cation distributed along a molecular backbone, wherein the ionene unit has antimicrobial functionality, wherein the molecular backbone is degradable; and
electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting, wherein the ionene unit has a chemical structure selected from the group consisting of:

wherein n is a first integer greater than or equal to one and less than or equal to one thousand, wherein m is a second integer greater than or equal to one and less than or equal to one thousand, wherein y is a third integer greater than or equal to one and less than or equal to one thousand, wherein x is a fourth integer greater than or equal to one and less than or equal to one thousand, and wherein ED 2000 is a poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) bis(2-aminopropyl ether) structure having a molecular weight greater than or equal to 1900 grams per mole and less than or equal to 2200 grams per mole.

Assignees

• IBM
• Agency Science Tech & Res

Inventors

• Fevre Mareva B
• Hedrick James L
• Park Nathaniel H
• Piunova Victoria A
• Tan Pang Kern Jeremy
• Yang Chuan
• Yang Yi Yan

Classifications

• A61P31/06 Primary

  for tuberculosis · CPC title

• C07C13/47

  with a bicyclo ring system containing ten carbon atoms · CPC title

• A61K31/787

  containing heterocyclic rings having nitrogen as a ring hetero atom · CPC title

• C08G73/0273

  Polyamines containing heterocyclic moieties in the main chain · CPC title

• C08G73/0293

  Quaternisation of polyamidoamines · CPC title