Medical liquid composition for aerial administration
US-2024358636-A1 · Oct 31, 2024 · US
Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation
US10836836B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10836836-B2 |
| Application number | US-202016789598-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 13, 2020 |
| Priority date | Apr 5, 2016 |
| Publication date | Nov 17, 2020 |
| Grant date | Nov 17, 2020 |
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- Title
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Abstract
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Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
First claim
Opening claim text (preview).
That which is claimed is: 1. A method for producing a composition for solid dispersion, comprising the step of removing a solvent from a solution comprising the hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively, a drug and the solvent. 2. The method according to claim 1 , wherein the hypromellose acetate succinate powder has a specific surface area of from 2.0 to 5.0 m 2 /g or more. 3. The method according to claim 1 , wherein the hypromellose acetate succinate powder has a loose bulk density of from 0.10 to 0.25 g/mL. 4. The method according to claim 1 , wherein the hypromellose acetate succinate powder comprises 10% by weight or less of component not soluble at 20° C. in such a weight of acetone as to be 10 times the weight of the powder.
Assignees
Inventors
Classifications
Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose · CPC title
- A61K47/38Primary
Cellulose; Derivatives thereof · CPC title
- A61K9/2866Primary
Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose · CPC title
- C08B13/00Primary
Preparation of cellulose ether-esters · CPC title
Processes · CPC title
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- What does patent US10836836B2 cover?
- Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also…
- Who is the assignee on this patent?
- Shinetsu Chemical Co
- What technology area does this patent fall under?
- Primary CPC classification A61K47/38. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 17 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).