Dialysis solution

Patent metadata

Field	Value
Publication number	US-10835660-B2
Application number	US-201515512789-A
Country	US
Kind code	B2
Filing date	Sep 15, 2015
Priority date	Sep 18, 2014
Publication date	Nov 17, 2020
Grant date	Nov 17, 2020

Abstract

The present invention relates to a dialysis solution containing bicarbonate, calcium and phosphate, wherein the dialysis solution contains phosphate having a concentration in the range from up to 0.4 mmol/l, preferably in the range from up to 0.375 mmol/l, or in the range from up to 0.25 mmol/l, and particularly preferably in the range from up to 0.2 mmol/l.

First claim

The invention claimed is:

1. A two-chamber bag comprising first and second chambers holding first and second individual solutions, respectively, which first and second individual solutions are configured to form a ready-to-use dialysis solution upon mixing with one another, wherein
the first individual solution contains calcium, magnesium, and chloride, does not contain sodium, and has a pH in the range of 2.4 to 3.0,
the second individual solution contains sodium, chloride, bicarbonate, and phosphate, has a volume greater than the first individual solution, and has a pH in the range of 7.0 to 7.8, and
the ready-to-use dialysis solution contains the phosphate in a concentration of up to 0.4 mmol/l, the calcium, and the bicarbonate.

2. A bag in accordance with claim 1 , characterized in that the dialysis solution contains the phosphate in a concentration range from 0.05 mmol/l to 0.25 mmol/l.

3. A bag in accordance with claim 1 , characterized in that the dialysis solution comprises the phosphate in a concentration of 0.05 mmol/l-0.4 mmol/l.

4. A bag accordance with claim 1 , characterized in that the dialysis solution further contains electrolytes and at least one osmotic agent or at least one carbohydrate compound.

5. A bag in accordance with claim 1 , characterized in that the first individual solution further does not contain at least one of hydrogen carbonate and phosphate.

6. A bag in accordance with claim 1 , characterized in that the second individual solution does not contain at least one of calcium, magnesium, potassium, and glucose.

7. A bag in accordance with claim 1 further comprising a separating means which separates the two chambers from one another, wherein the separating means is opened by pressure on one of the chambers.

8. A bag in accordance with claim 1 further comprising a seam which separates the two chambers from one another, wherein the seam is opened by pressure on one of the chambers.

9. A bag in accordance with claim 1 , characterized in that the dialysis solution contains the phosphate in a concentration of up to 0.375 mmol/l.

10. A bag in accordance with claim 1 , characterized in that the dialysis solution contains the phosphate in a concentration of up to 0.25 mmol/l.

11. A bag in accordance with claim 1 , characterized in that the dialysis solution contains the phosphate in a concentration of up to 0.2 mmol/l.

12. A bag in accordance with claim 1 , characterized in that the dialysis solution further contains electrolytes and at least one osmotic agent or glucose.

13. A bag in accordance with claim 1 , characterized in that the dialysis solution further contains electrolytes and at least one osmotic agent or glucose.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Huppert Jochen
• Mathis Pascal
• Berlich Robert

Classifications

• A61K9/08 Primary

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• A61K33/00

  Medicinal preparations containing inorganic active ingredients · CPC title

• A61K33/10

  Carbonates; Bicarbonates · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title