Flow balancing devices, methods, and systems

Patent metadata

Field	Value
Publication number	US-10835658-B2
Application number	US-201916381358-A
Country	US
Kind code	B2
Filing date	Apr 11, 2019
Priority date	Oct 10, 2014
Publication date	Nov 17, 2020
Grant date	Nov 17, 2020

Abstract

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

First claim

The invention claimed is:

1. A flow balancing system for a blood treatment device, comprising:
one or more inflow pumps and one or more outflow pumps positioned to engage a replaceable fluid circuit to pump fluid into and out of the blood treatment device, respectively;
at least one adjustable flow-restricting actuator configured to generate a flow restriction of a selected magnitude in at least one portion of the replaceable fluid circuit, the at least one adjustable flow-restricting actuator located at an inlet of a respective one of said one or more inflow pumps and one or more outflow pumps to generate a selectable suction head during pumping;
valve actuators that control valve portions of the replaceable fluid circuit;
a controller connected to said one or more inflow and outflow pumps and configured to control speeds thereof, configured to control said valve actuators, and configured to control said at least one adjustable flow-restricting actuator;
the controller having a data store storing a model that predicts data indicative of a flow rate based on at least one of pump speed and inlet and/or outlet pressure of each of said one or more inflow and outflow pumps;
the replaceable fluid circuit having at least an inflow channel, an outflow channel, and a branch channel, the inflow channel and the outflow channel connecting to the blood treatment device, the inflow channel and the outflow channel being connected to the branch channel such that the inflow and outflow channels can be bridged by the valve actuators to cause fluid flowing in the inflow channel to bypass the blood treatment device and to flow from the inflow channel through the branch channel to the outflow channel;
the branch channel including an accumulator with an internal volume that is selectable in flow communication with the branch channel;
one or more pressure sensors interoperable with the branch channel and configured to detect pressure at a respective one or more points along the branch channel;
the controller being programmed to generate a test command and in response thereto, perform a calibration operation during which it bridges the inflow and outflow channels through said branch channel and to calculate a difference in flow rates between the one or more inflow pumps and the one or outflow pumps through said branch channel and, responsively thereto, to calculate adjustments to the model; and
the controller being programmed to control the one or more inflow and outflow pumps responsively to the model.

2. The system of claim 1 , wherein the difference in flow rates between the one or more inflow pumps and the one or more outflow pumps through said branch channel is calculated from pressure signals indicating a pressure drop in the branch channel.

3. The system of claim 1 , wherein the difference in flow rates between the one or more inflow pumps and the one or more outflow pumps through said branch channel is calculated from a single pressure signal indicating a net inflow or net outflow from the branch channel.

4. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined operating time interval of one of the one or more inflow and outflow pumps.

5. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined number of rotations of the one or more inflow and outflow pumps.

6. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined net flow volume derived numerically from a number of rotations of the one or more inflow and outflow pumps.

7. The system of claim 1 , wherein the controller is programmed to adjust the at least one adjustable flow-restricting actuator to generate an inlet pressure of one of the one or more inflow and outflow pumps during the calibration operation.

8. The system of claim 1 , wherein the controller is programmed to adjust the at least one adjustable flow-restricting actuator to generate a first inlet pressure at one of the one or more inflow and outflow pumps during the calibration operation matching a second inlet pressure occurring during a treatment operation.

9. The system of claim 1 , wherein the controller is programmed to adjust the at least one adjustable flow-restricting actuator to generate multiple first inlet pressures at one of the one or more inflow and outflow pumps during the calibration operation.

10. The system of claim 9 , wherein the difference in flow rates between the one or more inflow pumps and the one or more outflow pumps through said branch channel is calculated from pressure signals indicating a pressure drop in the branch channel.

11. The system of claim 9 , where in the difference in flow rates between the one or more inflow pumps and the one or more outflow pumps through said branch channel is calculated from a single pressure signal indicating a net inflow or net outflow from the branch channel.

12. The system of claim 9 , wherein the controller is programmed to generate the test command upon the detection of a predefined operating time interval of one of the one or more inflow and outflow pumps.

13. The system of claim 9 , wherein the controller is programmed to generate the test command upon the detection of a predefined number of rotations of the one or more inflow and outflow pumps.

14. The system of claim 9 , wherein the controller is programmed to generate the test command upon the detection of a predefined net flow volume derived numerically from a number of rotations of the one or more inflow and outflow pumps.

15. The system of claim 9 , wherein the controller is programmed to adjust the at least one adjustable flow-restricting actuator to generate an inlet pressure of one of the one or more inflow and outflow pumps during the calibration operation.

16. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined temperature of the replaceable fluid circuit.

17. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined temperature or temperature change of the replaceable fluid circuit.

18. The system of claim 1 , wherein the controller is programmed to generate the test command upon the detection of a predefined pressure or pressure change of at a location in the replaceable fluid circuit.

19. The system of claim 1 , wherein the controller is programmed to control said valve actuators to recover fluid flowing through the branch channel for use in a treatment.

20. The system of claim 9 , wherein the replaceable fluid circuit includes a storage vessel in communication with the outflow channel and the inflow channel and the controller is configured to direct fluid flowing through the branch channel to said storage vessel and from the storage vessel to the inflow channel during a treatment, whereby fluid flowing in said branch channel is recovered for use during treatment.

21. The system of claim 1 , wherein the controller calculates a difference in flow rates between the one or more inflow pumps and the one or more outflow pumps through said branch channel responsively to a moving time-average pressure drop or pressure generated from a non-rectangular averaging window.

22. The system of claim 1 , wherein the controller calculates a difference in flow rates between the one or more inflow pumps and the one or more out

Assignees

• Nxstage Medical Inc

Inventors

• Burbank Jeffrey H
• Treu Dennis M
• Rubery Jr Daniel J
• Newell Scott W
• Brugger James M
• Schnell William J
• Weigel William K
• White Steven A
• Wyeth Mark T
• James Jerome
• Desouza David
• Turk Jr Joseph E
• Casey Garrett

Classifications

• A61M1/3607

  Regulation parameters · CPC title

• A61M1/34

  Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration · CPC title

• A61M2205/3355

  Controlling downstream pump pressure · CPC title

• A61M2205/3368

  Temperature · CPC title

• A61M1/3635

  Constructional details · CPC title