Singlet oxygen generating device for selective destruction of pathogens

Patent metadata

Field	Value
Publication number	US-10835629-B2
Application number	US-201715729005-A
Country	US
Kind code	B2
Filing date	Oct 10, 2017
Priority date	Oct 7, 2016
Publication date	Nov 17, 2020
Grant date	Nov 17, 2020

Abstract

A device for generating singlet oxygen is provided. The device has elongated posts extending from a surface, the lateral sides of which have particles with a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. An optical fiber conveys light to the sensitizer and a gas supply tube conveys oxygen to the sensitizer. The device is configured to keep the sensitizer from contacting external fluids, such as saliva.

First claim

What is claimed is:

1. A device for generating singlet oxygen, the device comprising:
a hand-piece comprising
a conical tip at a terminus of the hand-piece;
a gas supply tube that conveys oxygen to the conical tip;
an optical fiber that conveys light to the conical tip;
wherein the conical tip is detachable from the hand-piece and comprises:
a cylindrical substrate with an internal surface that is at least partially coated with particles that comprise a sensitizer, wherein the sensitizer converts triplet oxygen to singlet oxygen upon exposure to light;
the optical fiber conveys light to the sensitizer;
the gas supply tube is disposed upstream of the sensitizer such that oxygen is conveyed to the sensitizer;
at least one opening disposed downstream of the sensitizer that directs singlet oxygen to a treatment site;
a hydrophobic barrier that separates the sensitizer particles from the at least one opening, thereby protecting the sensitizer from contacting an external fluid.

2. The device as recited in claim 1 , wherein the hydrophobic barrier comprises a semi-permeable membrane.

3. The device as recited in claim 1 , wherein the hydrophobic barrier comprises a semi-permeable membrane wherein the semi-permeable membrane has pores with a diameter of between 0.4 nm and 1,000 nm.

4. The device as recited in claim 1 , wherein the particles are between 10 microns and 100 microns in diameter.

5. The device as recited in claim 1 , wherein the particles are between 1 nm and 10 microns in diameter.

6. The device as recited in claim 1 , wherein the particles are between 1 nm and 500 nm in diameter.

7. The device as recited in claim 1 , wherein the particles are comprised of a second material whose composition is different than a composition of the sensitizer and the particles are between 1 micron and 500 microns in diameter.

8. The device as recited in claim 7 , wherein the second material is glass.

9. The device as recited in claim 7 , wherein the sensitizer is a silicon-phthalocyanine and the second material is a sol-gel material.

10. The device as recited in claim 1 , where the hand-piece has a length to width ratio of at least 5:1.

11. The device as recited in claim 1 , wherein the optical fiber that conveys light to the conical tip in configured to convey a light having a first wavelength, the device further comprising a second optical fiber that conveys light having a second wavelength to the conical tip, wherein the sensitizer does not absorb the second wavelength.

12. The device as recited in claim 1 , wherein the cylindrical substrate is optically transparent.

13. The device as recited in claim 1 , further comprising a disposable sheath between the hand-piece and the conical tip, wherein the device has a length to width ratio of at least 10:1.

14. The device recited in claim 1 wherein the hydrophobic barrier is comprised of a plurality of elongated posts extending from the internal surface of the cylindrical substrate, each elongated post comprising the particles.

15. The device as recited in claim 14 , wherein the hydrophobic barrier provides a superhydrophobic surface.

16. The device recited in claim 14 , wherein each elongated post has a top and the tops of the elongated posts are coated with inert hydrophobic particles.

17. The device recited in claim 14 wherein the elongated posts are circumscribed with a plurality of guard posts, each guard post being coated with inert hydrophobic particles.

18. The device as recited in claim 14 , wherein the elongated posts comprise polydimethylsiloxane (PDMS) and the particles are coated onto the lateral sides of the PDMS.

19. The device recited in claim 1 wherein the hydrophobic barrier is comprised of a plurality of elongated ridges extending from the internal surface of the cylindrical substrate, each elongated ridge comprising the particles.

20. A method for treating a periodontal pocket of a patient with singlet oxygen, the method comprising:
conveying a gas comprising triplet oxygen through a hand-piece, the hand-piece comprising
a conical tip at a terminus of the hand-piece;
a gas supply tube that conveys oxygen to the conical tip;
an optical fiber that conveys light to the conical tip;
wherein the conical tip is detachable from the hand-piece and comprises:
a cylindrical substrate with an internal surface that is at least partially coated with particles that comprise a sensitizer, wherein the sensitizer converts the triplet oxygen to singlet oxygen upon exposure to light;
the optical fiber conveys light to the sensitizer;
the gas supply tube is disposed upstream of the sensitizer such that oxygen is conveyed to the sensitizer;
at least one opening disposed downstream of the sensitizer that directs singlet oxygen to a treatment site;
a hydrophobic barrier that separates the sensitizer particles from the at least one opening, thereby protecting the sensitizer from contacting an external fluid.

inserting the at least one opening of the conical tip into the periodontal pocket of the patient such that the at least one opening is proximate the treatment site;
actuating a light source that provides light to the optical fiber, thereby converting the triplet oxygen to the singlet oxygen using the sensitizer;
permitting the singlet oxygen to flow from the sensitizer to the at least one opening and then to the treatment site, thereby treating the periodontal pocket of the patient with the singlet oxygen.

Assignees

• Univ City New York Res Found
• Singleto2 Therapeutics Llc

Inventors

• Lyons Alan M
• Greer Alexander
• Xu Qianfeng

Classifications

• A61C3/005 Primary

  Brushes for applying dental compositions · CPC title

• C01B13/0203

  from inorganic compounds · CPC title

• A61C19/043

  Depth measuring of periodontal pockets; Probes therefor · CPC title

• A61C8/0006

  Periodontal tissue or bone regeneration (support means for endoprosthetic bone substitute or bone graft implants A61F2/2846) · CPC title

• A61L2/20

  Gaseous substances, e.g. vapours · CPC title