Parallel separation system

Patent metadata

Field	Value
Publication number	US-10830740-B2
Application number	US-201113638676-A
Country	US
Kind code	B2
Filing date	Mar 30, 2011
Priority date	Mar 31, 2010
Publication date	Nov 10, 2020
Grant date	Nov 10, 2020

Abstract

A method in a separation system including parallel fluid paths each having a separation module, includes providing a sensor of the same type in at least each of the parallel fluid paths except one: measuring a characteristic fluid property with at least one of the sensors in the parallel fluid paths; possibly measuring the same characteristic fluid property with a system sensor positioned in the outlet of the separation system; and comparing measured characteristic fluid properties to evaluate and/or qualify the performance of the separation system.

First claim

The invention claimed is:

1. A method in a separation system comprising the steps of:
providing:
(i) a plurality of parallel fluid paths, each fluid path comprising a separation module and a sensor;
wherein, each sensor is a disposable probe independently positioned within each parallel fluid path downstream of the respective separation module;
(ii) an inlet fluid path and an outlet fluid path, both being in fluidic connection to the separation modules;
(ii) a system sensor positioned in the outlet fluid path; and
(iv) a control system;
initiating operation of the separation modules simultaneously, and measuring a characteristic fluid property of each separation module via the sensors downstream of the separation modules while measuring the same characteristic fluid property of the combined parallel fluid paths via the system sensor;
comparing the measured characteristic fluid property measured by the system sensor to the characteristic fluid property measured by each sensor corresponding to the respective separation module, to evaluate performance of the separation system; and
sequentially adjusting the characteristic fluid property of the respective separation module based on the measured characteristic flow property measured by the system sensor, by sequentially accessing and modifying a position of an associated control valve, via the control system.

2. The method of claim 1 , wherein the evaluation of the separation system comprises measurement of residence time or chromatographic efficiency.

3. The method of claim 1 , further comprising comparing sensor response from at least one sensor in one of the parallel paths with the sensor response of the separation system sensor.

4. The method of claim 1 , wherein the characteristic fluid property is one or more of type fluid flow rate, force, pressure, temperature, conductivity or pH.

5. The method of claim 1 , wherein the comparison of sensor responses is done for the purpose of qualifying, monitoring or documenting the performance of the separation system.

6. The method of claim 1 , wherein the characteristic fluid property is one or more of absorbance, reflectance, or emission of light.

Assignees

• Gebauer Klaus
• Cytiva Bioprocess R & D Ab

Inventors

• Gebauer Klaus

Classifications

• G01N30/78

  using more than one detector · CPC title

• G01N30/467 Primary

  all columns being identical · CPC title

• G01N30/8665

  for calibrating the measuring apparatus · CPC title

• B01D15/1885

  placed in parallel · CPC title