Antioxidant complex for reducing number of somatic cell in livestock animal, and preparation method and application thereof

Patent metadata

Field	Value
Publication number	US-10828277-B2
Application number	US-201515540002-A
Country	US
Kind code	B2
Filing date	Dec 18, 2015
Priority date	Feb 16, 2015
Publication date	Nov 10, 2020
Grant date	Nov 10, 2020

Abstract

Provided are an antioxidant complex for reducing the number of somatic cells in a livestock animal and a preparation method and application thereof. Active components of the preparation are melatonin (MT) having a centration of 2-30 g/L and vitamin C having a concentration of 1-14.3 g/L. The antioxidant complex provided in the present invention can effectively reduce the number of somatic cells in a diary cow and improve milk quality.

First claim

What is claimed is:

1. A method of improving milk quality by administering an antioxidant preparation to a dairy cow with a somatic cell count greater than 100,000/mL for reducing the number of somatic cells in the dairy cow, characterized in that the preparation is in a form of an injection and comprises a combination of purified melatonin and vitamin C as active components, wherein four injections are administered at a neck of the dairy cow on four sequential days, wherein the administration comprises injecting 2 mL of the preparation to the dairy cow, wherein the concentration of the purified melatonin in the preparation is 1-23.2 g/L and the concentration of the vitamin C in the preparation is 1-14.3 g/L.

2. The method according to claim 1 , wherein concentration of the purified melatonin is 2.32 g/L.

3. The method according to claim 1 , wherein concentration of the vitamin C is 8.8 g/L.

4. The method according to claim 1 , wherein the antioxidant preparation is produced by a method comprising dissolving vitamin C in 75% ethanol solution followed by addition of melatonin, the operation process being carried out in dark.

5. The method according to claim 1 , wherein the concentration of the purified melatonin in the preparation is 2.32 g/L and the concentration of the vitamin C in the preparation is 8.8 g/L.

Assignees

• Univ China Agricultural

Inventors

• Liu Guoshi

Classifications

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title

• A61K2039/55511

  Organic adjuvants · CPC title

• A61K38/17

  from animals; from humans {(enzyme inhibitors A61K38/005)} · CPC title

• A61K39/39

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title