Process for producing a nanofibrillar cellulose hydrogel

Patent metadata

Field	Value
Publication number	US-10822743-B2
Application number	US-201615578778-A
Country	US
Kind code	B2
Filing date	Jun 2, 2016
Priority date	Jun 4, 2015
Publication date	Nov 3, 2020
Grant date	Nov 3, 2020

Abstract

A process for producing a nanofibrillar cellulose hydrogel comprises obtaining bleached cellulose pulp fibers and providing an aqueous suspension thereof; and subjecting the cellulose pulp fibers in the aqueous suspension to at least 2 cycles of high pressure mechanical disintegration to obtain a nanofibrillar cellulose hydrogel and thereby reducing the number of viable microorganisms present in the suspension by a factor of at least 10 2 ; wherein all steps of the process after obtaining the bleached cellulose pulp fibers are performed under conditions of ISO 8 of ISO 14644-1 cleanroom standards or stricter. A nanofibrillar cellulose hydrogel, a system for producing the same and the use of a disintegrating apparatus are also disclosed.

First claim

The invention claimed is:

1. A process for producing a nanofibrillar cellulose hydrogel, wherein the process comprises:
obtaining bleached cellulose pulp fibers and providing an aqueous suspension thereof; and
subjecting the cellulose pulp fibers in the aqueous suspension to at least 2 cycles of high pressure mechanical disintegration to obtain a nanofibrillar cellulose hydrogel and thereby reducing the number of viable microorganisms present in the suspension by a factor of at least 10 2 ,
wherein all steps of the process after obtaining the bleached cellulose pulp fibers are performed under conditions of ISO 8 of ISO 14644-1 cleanroom standards or stricter.

2. The process according to claim 1 , wherein the process further comprises washing the cellulose pulp fibers with a sterile liquid prior to subjecting to the high pressure mechanical disintegration.

3. The process according to claim 1 , wherein the process further comprises prerefining the cellulose pulp fibers to break down the cellulose pulp fibers prior to subjecting to the high pressure mechanical disintegration.

4. The process according to claim 1 , wherein the high pressure mechanical disintegration is conducted using a pressure type homogenizer.

5. The process according to claim 1 , further comprising subjecting the cellulose pulp fibers in the aqueous suspension to at least 2 cycles of high pressure mechanical disintegration to obtain a nanofibrillar cellulose hydrogel and thereby reducing the number of viable microorganisms present in the suspension by a factor of at least 10 3 .

6. The process according to claim 1 , further comprising subjecting the cellulose pulp fibers in the aqueous suspension to 2 to 10 cycles of high pressure mechanical disintegration.

7. The process according to claim 1 , wherein the process further comprises subjecting the nanofibrillar cellulose hydrogel to a further decontamination treatment for reducing the number of viable micro-organisms in the nanofibrillar cellulose hydrogel by a factor of at least 10 2 .

8. The process according to claim 7 , wherein the further decontamination treatment comprises subjecting the nanofibrillar cellulose hydrogel to non-ionizing or ionizing radiation.

9. The process according to claim 7 , wherein the further decontamination treatment comprises subjecting the nanofibrillar cellulose hydrogel to a heat treatment, wherein the heat treatment comprises keeping the nanofibrillar cellulose hydrogel at a temperature in the range of 72° C. to 100° C. for at least 15 seconds.

10. The process according to claim 7 , wherein the further decontamination treatment comprises subjecting the nanofibrillar cellulose hydrogel to pulsed electric field processing.

11. The process according to claim 7 , wherein the pH of the nanofibrillar cellulose hydrogel after the further decontamination treatment is at most 0.4 pH units lower than the pH of the nanofibrillar cellulose hydrogel before the further decontamination treatment.

12. The process according to claim 1 , whereby a non-autoclaved nanofibrillar cellulose hydrogel that includes fewer than 10 −1 CFU of a viable micro-organism for a unit of 1 gram of the nanofibrillar cellulose hydrogel is obtained.

13. The process according to claim 1 , wherein the process further comprises maintaining conditions of ISO 5 of ISO 14644-1 cleanroom standards or stricter from the high pressure mechanical disintegration to packaging the nanofibrillar cellulose hydrogel.

14. The process according to claim 1 , wherein the number of viable microorganisms is reduced during the process by a factor of at least 10 3 .

15. The process according to claim 1 , wherein the nanofibrillar cellulose is native or anionic nanofibrillar cellulose.

16. The process of claim 1 , wherein the consistency of the aqueous suspension subjected to the high pressure mechanical disintegration is at least 0.7% (w/w).

17. A method of producing nanofibrillar cellulose hydrogel, the method comprising:
obtaining bleached cellulose pulp fibers directly from a pulp mill libertine, and providing an aqueous suspension thereof; and
subjecting the cellulose pulp fibers in the aqueous suspension to at least 2 cycles of high pressure mechanical disintegration to obtain a nanofibrillar cellulose hydrogel, thereby reducing the number of viable microorganisms present in the suspension by a factor of at least 10 2 ,
wherein all steps of the process after obtaining the bleached cellulose pulp fibers are performed under conditions of ISO 8 of ISO 14644-1 cleanroom standards or stricter.

18. The method of claim 17 , further comprising bleaching the cellulose pulp fibers in the pulp mill fiberline using an oxidizing process comprising acidic and alkaline conditions.

Assignees

• Upm Kymmene Corp

Inventors

• Kajanto Isko
• Nuopponen Markus

Classifications

• A61K31/717 Primary

  Celluloses · CPC title

• A61K8/731

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61L2/00

  Disinfection or sterilisation of materials or objects, in general; Accessories therefor · CPC title

• C08L1/02

  Cellulose; Modified cellulose · CPC title

• C12N5/0018

  Culture media for cell or tissue culture (media for specific animal cell type C12N5/06) · CPC title