Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof

Patent metadata

Field	Value
Publication number	US-10821077-B2
Application number	US-201815903275-A
Country	US
Kind code	B2
Filing date	Feb 23, 2018
Priority date	Oct 25, 2002
Publication date	Nov 3, 2020
Grant date	Nov 3, 2020

Abstract

The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.

First claim

What is claimed is:

1. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i. a dicarboxylic acid ester;
ii. about 0.1% to about 5% by weight of the carrier of at least one surface-active agent;
iii. about 2% to about 50% by weight of the carrier of at least one hydrophobic solvent; and
iv. water,
wherein the composition does not comprise a polymeric gelling agent; and
wherein upon release from a foam dispenser, a foam is produced.

2. The foamable composition of claim 1 , wherein the carrier is an emulsion.

3. The foamable composition of claim 1 , wherein the at least one surface-active agent has a hydrophilic/lipophilic balance (HLB) value of between about 9 and about 14.

4. The foamable composition of claim 1 , further comprising a retinoid.

5. The foamable composition of claim 4 , wherein the dicarboxylic acid ester is diisopropyl adipate and the at least one hydrophobic solvent is mineral oil.

Assignees

• Foamix Pharmaceuticals Ltd

Inventors

• Tamarkin Dov
• Friedman Doron
• Berman Tal
• Ziv Enbal
• Schuz David

Classifications

• A61K8/86

  Polyethers · CPC title

• A61K8/4993

  Derivatives containing from 2 to 10 oxyalkylene groups · CPC title

• A61K8/37

  Esters of carboxylic acids · CPC title

• A61K8/362

  Polycarboxylic acids · CPC title

• A61Q17/02

  containing insect repellants · CPC title