Compositions and methods for measurement of analytes
US-2016274030-A1 · Sep 22, 2016 · US
US10809242B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10809242-B2 |
| Application number | US-201515311889-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 19, 2015 |
| Priority date | May 19, 2014 |
| Publication date | Oct 20, 2020 |
| Grant date | Oct 20, 2020 |
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Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.
Opening claim text (preview).
The invention claimed is: 1. A method for the detection of an analyte on a sample, the method comprising: contacting the sample with a swab comprising at least one type of electrospun nanofiber and at least one colorimetric reactant, the electrospun nanofiber comprises a brittle shell and a core, said core comprises the at least one colorimetric reactant, and said brittle shell has a glass transition between 70° C. to 150° C., and is breakable under normal stress of 0.08-1 kg/cm2 at a temperature range of −55 ° C. to 60° C., wherein: said contracting is by applying normal stress between said swab and said sample, said stress is sufficient for breaking the electrospun shell; a colorimetric change within the swab indicates that the sample has at least trace amounts of the analyte, thereby detecting said analyte on said surface; and said analyte is in a solid state, in a liquid state or both. 2. The method of claim 1 , wherein said analyte is a hazardous substance. 3. The method of claim 2 , wherein said hazardous substance is an explosive substance.
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