Inducing internal apoptosis in malignant tumors by positive electrostatic charges

Patent metadata

Field	Value
Publication number	US-10806945-B2
Application number	US-201816027315-A
Country	US
Kind code	B2
Filing date	Jul 4, 2018
Priority date	Jul 4, 2017
Publication date	Oct 20, 2020
Grant date	Oct 20, 2020

Abstract

A method for tumor suppression is disclosed. The method includes preparing a chip by forming a layer of electrically conductive nanostructures on a substrate, placing the chip adjacent to a cancerous tumor, positively charging the layer of electrically conductive nanostructures by applying a positive electrostatic voltage on the chip, and reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures.

First claim

What is claimed is:

1. A method for tumor suppression, comprising:
preparing a chip by forming a layer of electrically conductive nanostructures on a substrate;
placing the chip adjacent to a cancerous tumor;
positively charging the layer of electrically conductive nanostructures by applying a positive electrostatic voltage on the chip, comprising:
connecting the chip to a direct current (DC) power generator; and
applying a positive DC voltage between 10 V and 70 V on the chip; and

reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures.

2. The method of claim 1 , wherein placing the chip adjacent to the cancerous tumor comprises placing the chip in a position located at a distance less than 10 cm from the cancerous tumor.

3. The method of claim 1 , wherein placing the chip adjacent to the cancerous tumor comprises:
forming an electrically conductive patch by attaching the chip onto an adhesive substrate;
attaching the electrically conductive patch onto skin of a patient at a location adjacent to the cancerous tumor; and
filling an interfacial area between the electrically conductive patch and the skin of the patient with a biocompatible electrical insulator layer.

4. The method of claim 1 , wherein the chip comprises:
a layer of silicon (Si);
a layer of silicon dioxide (SiO 2 ) grown on the layer of silicon;
a catalyst layer deposited on the layer of SiO 2 ; and
an array of electrically conductive nanostructures grown on the catalyst layer.

5. The method of claim 1 , wherein preparing the chip by forming the layer of electrically conductive nanostructures on the substrate comprises:
growing a layer of SiO 2 on a silicon wafer;
depositing a catalyst layer on the layer of SiO 2 ; and
forming the layer of electrically conductive nanostructures on the catalyst layer.

6. The method of claim 1 , wherein the layer of electrically conductive nanostructures comprises at least one of carbon nanotubes (CNTs), vertically aligned multi-walled carbon nanotube (VAMWCNTs), graphene, zinc dioxide (ZnO), Silicon nanowires (SiNWs), Silicon nanograss, TiO 2 nanotubes, TiO 2 nanowires, metallic layers and combinations thereof.

7. The method of claim 1 , wherein electrostatically stimulating cancer cells of the cancerous tumor comprises internal apoptosis of the cancer cells in the cancerous tumor induced by positive charges accumulated on the layer of electrically conductive nanostructures due to a negative charge of the cancer cells.

8. The method of claim 1 , wherein electrostatically stimulating cancer cells of the cancerous tumor comprises no stimulation of healthy (normal) cells placed either within the cancerous tumor or nearby areas of the cancerous tumor.

9. The method of claim 1 , wherein reducing size of the cancerous tumor comprises a decrease in the size of the cancerous tumor by at least more than 30%.

10. The method of claim 1 , wherein reducing size of the cancerous tumor comprises elimination of the cancerous tumor.

11. A method for tumor suppression, comprising:
preparing a chip by forming a layer of electrically conductive nanostructures on a substrate;
placing the chip adjacent to a cancerous tumor;
positively charging the layer of electrically conductive nanostructures by applying a positive electrostatic voltage on the chip; and
reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures,
wherein positively charging the layer of electrically conductive nanostructures by applying the positive electrostatic voltage on the chip, and reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures are done in less than one week.

12. A method for tumor suppression, comprising:
preparing a chip by forming a layer of electrically conductive nanostructures on a substrate;
placing the chip adjacent to a cancerous tumor;
positively charging the layer of electrically conductive nanostructures by applying a positive electrostatic voltage on the chip; and
reducing size of the cancerous tumor by electrostatically stimulating cancer cells of the cancerous tumor responsive to accumulating positive charges on the layer of electrically conductive nanostructures,
wherein electrostatically stimulating cancer cells of the cancerous tumor comprises no stimulation of healthy (normal) cells due to a low negative charge of healthy (normal) cells.

Assignees

• Abdolahad Mohammad
• Rafizadeh Tafti Saeed
• Zandi Ashkan

Inventors

• Abdolahad Mohammad
• Rafizadeh Tafti Saeed
• Zandi Ashkan

Classifications

• G01N33/57555

  of the prostate · CPC title

• G01N33/57515

  of the breast · CPC title

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/36002

  Cancer treatment, e.g. tumour · CPC title

• A61N1/205

  for promoting a biological process · CPC title