Adherent resorbable matrix

Patent metadata

Field	Value
Publication number	US-10806833-B1
Application number	US-77101710-A
Country	US
Kind code	B1
Filing date	Apr 30, 2010
Priority date	May 11, 2009
Publication date	Oct 20, 2020
Grant date	Oct 20, 2020

Abstract

The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

First claim

What is claimed is:

1. An adherent resorbable porous device for regenerating meningeal tissue in a patient, comprising:
a biocompatible and resorbable collagen matrix sheet-having pores of sizes that permit growing meningeal tissue to infiltrate therein, and
an adhesive layer having a thickness between 0.10 mm to 1 mm of dried hydroxypropyl methyl cellulose or hydroxyethyl cellulose adhesive on only one surface of the collagen matrix sheet, which when contacted with aqueous fluid provides adherence to a surface of the meningeal tissue and allows infiltration of cells of the meningeal tissue into the collagen matrix sheet,
wherein the adhesive layer provides adherence to the surface of the meningeal tissue with an increased uniaxial adhesion from about 0.4N to about 10N as determined by ASTM F-2258-05; and
wherein the adherent resorbable porous device has a porous structure that facilitates ingrowth of cells into the collagen matrix.

2. The adherent resorbable porous device of claim 1 further including a bioactive agent.

3. The adherent resorbable porous device of claim 1 wherein the hydroxypropyl methyl cellulose or hydroxyethyl cellulose has a molecular weight between 5 kDa and 2000 kDa.

4. The adherent resorbable porous device of claim 1 wherein the hydroxypropyl methyl cellulose or hydroxyethyl cellulose has a molecular weight between 10 kDa and 1500 kDa.

5. The adherent resorbable porous device of claim 1 wherein the adhesive layer includes a dye coloring agent.

6. The adherent resorbable porous device of claim 1 wherein the matrix sheet includes a dye coloring agent.

7. The adherent resorbable porous device of claim 1 wherein the matrix sheet and the adhesive layer include a dye coloring agent.

8. The adherent resorbable porous device of claim 7 wherein the matrix sheet and the adhesive layer are different colors.

9. The adherent resorbable porous device of claim 1 wherein the matrix sheet has a thickness from 2.5 mm to 5 mm.

10. The adherent resorbable porous device of claim 1 wherein the matrix sheet is a collagen sponge.

11. The adherent resorbable porous device of claim 1 wherein the matrix sheet has a thickness from 1.0 mm to 5 mm.

12. The adherent resorbable porous device of claim 1 wherein the matrix sheet includes pores of from 1 μm to 1000 μm.

13. The adherent resorbable porous device of claim 1 wherein the matrix sheet includes pores of from 10 μm to 500 μm.

14. The adherent resorbable porous device of claim 1 , wherein the adhesive layer has a thickness between about 0.2 mm to about 0.5 mm.

15. The adherent resorbable porous device of claim 1 , wherein the adhesive layer has a thickness between about 0.3 mm to about 0.4 mm.

16. The adherent resorbable porous device of claim 1 , wherein the adhesive layer is formed on the collagen matrix sheet by applying a solution of the adhesive to one surface of the collagen matrix sheet when it is dry and then lyophilized.

17. The adherent resorbable porous device of claim 1 , which is prepared by evenly applying a solution of the adhesive onto one side of a lyophilized collagen matrix sheet, and then lyophilizing the collagen matrix sheet having the adhesive applied thereon.

Assignees

• Pomrink Gregory J
• Alkema Paul K
• Hubbard Raymond D
• Menon Riyesh
• Integra Lifesciences Corp

Inventors

• Pomrink Gregory J
• Alkema Paul K
• Hubbard Raymond D
• Menon Riyesh

Classifications

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L2300/442

  Colorants, dyes · CPC title