Method for measuring a plurality of status parameters of a fluid contained in a container

Patent metadata

Field	Value
Publication number	US-10802033-B2
Application number	US-201615736030-A
Country	US
Kind code	B2
Filing date	Apr 27, 2016
Priority date	Jul 6, 2015
Publication date	Oct 13, 2020
Grant date	Oct 13, 2020

Abstract

A method is provided for measuring status parameters of a fluid contained in a container ( 10 ). The container ( 10 ) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. The plate carries sensors (S 1 -S 5 ) that are in operative contact with the internal chamber of the container ( 10 ) and connected for data exchange ( 14 ) with an external control unit ( 16 ) that receives and processes the measurement data from the sensors (S 1 -S 5 ). The sensor plate also carries a temporarily inactive duplicate (D 1 -D 5 ) of at least one of the sensors (S 1 -S 5 ) that is activated if measurement data of the sensor (S 1 -S 5 ) is classified as atypical in the context of an integrity or plausibility test carried out by the external control unit ( 16 ).

First claim

The invention claimed is:

1. A method for measuring a plurality of status parameters of a fluid contained in a container ( 10 ), the container ( 10 ) being configured for a single use and has a wall on which a sensor carrier plate is fixed in a fluid-tight manner, the sensor carrying plate carrying a plurality of sensors (S 1 -S 5 , D 1 -D 5 ) that are disposed and configured to be operative contact with an internal space of the container ( 10 ) and are connected for data exchange ( 14 ) with an external control unit ( 16 ) that receives and processes measurement data from the sensors (S 1 -S 5 , D 1 -D 5 ), the sensors carried by the sensor carrier plate include at least one pair of sensors (S 1 -S 5 ) that includes a first sensor (S 1 -S 5 ) and a duplicate (D 1 -D 5 ) of the first sensor (S 1 -S 5 ), the method comprising:
operating the external control unit ( 16 ) to carry out an integrity or plausibility test using the measurement data of at least the first sensor (S 1 -S 5 ) while keeping the duplicate (D 1 -D 5 ) of the first sensor (S 1 -S 5 ) in a temporarily inactive state;
determining if the measurement data of at least the first sensor (S 1 -S 5 ) is atypical in the context of the integrity or plausibility test carried out by the external control unit ( 16 );
activating the duplicate (D 1 -D 5 ) of the first sensor (S 1 -S 5 ) if the measurement data of the first sensor (S 1 -S 5 ) is determined to be atypical in the context of the integrity or plausibility test carried out by the external control unit ( 16 ); and
determining whether processing of the measurement data received from the first sensor (S 1 -S 5 ) and from the duplicate (D 1 -D 5 ) of the first sensor provides the same results within a predetermined tolerance.

2. The method of claim 1 , further comprising:
operating the control unit ( 16 ) to temporarily processes both the measurement data received from the first sensor (S 1 -S 5 ) and the measurement data received from the duplicate (D 1 -D 5 ) of the first sensor.

3. The method of claim 1 , further comprising:
deactivating the duplicate (D 1 -D 5 ) of the first sensor if the processing of the measurement data received from the first sensor (S 1 -S 5 ) and from the duplicate (D 1 -D 5 ) of the first sensor provides the same results within a predetermined tolerance.

4. The method of claim 3 , further comprising:
deactivating the first sensor (S 1 -S 5 ) if the processing of the measurement data received from the first sensor (S 1 -S 5 ) and from the duplicate (D 1 -D 5 ) of the first sensor provides different results in consideration of the predetermined tolerance.

5. The method of claim 1 further comprising:
using the control unit ( 16 ) to process the measurement data received from the duplicate (D 1 -D 5 ) of the first sensor instead of the measurement data received from the first sensor (S 1 -S 5 ) if the measurement data received from the first sensor (S 1 -S 5 ) and from the duplicate (D 1 -D 5 ) of the first sensor provides the same results within a predetermined tolerance.

6. The method of claim 5 , further comprising:
reactivating the first sensor (S 1 -S 5 ) and deactivating the duplicate (D 1 -D 5 ) of the first sensor if the processing of the measurement data received from the duplicate (D 1 -D 5 ) of the first sensor and of the measurement data received, prior to activation of the duplicate (D 1 -D 5 ), from the first sensor (S 1 -S 5 ) provide the same results within a predetermined tolerance.

7. The method of claim 1 , further comprising:
calculating a parameter value by the external control unit, based on measurement data of a plurality of different sensors for a status parameter that cannot be directly measured by any of the sensors.

8. The method of claim 1 ,
wherein the container is a disposable bioreactor or a disposable mixing container.

9. The method of claim 8 , wherein the disposable bioreactor or the disposable mixing container are bags with a wall that has flexible segments, or as a plastic container, with a wall that has rigid segments.

Assignees

• Sartorius Stedim Biotech Gmbh

Inventors

• Becker Mario
• Greller Gerhard
• Grimm Christian
• Adams Thorsten
• Boettcher Lars
• Weichert Henry

Classifications

• B01F35/513

  Flexible receptacles, e.g. bags supported by rigid containers · CPC title

• B01F35/211

  of the operational parameters (B01F35/212 and B01F35/213 take precedence) · CPC title

• G01D3/10

  with provision for switching-in of additional or auxiliary indicators or recorders · CPC title

• C12M23/28

  disposable or single use · CPC title

• C12M23/14

  Bags · CPC title