Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording

Patent metadata

Field	Value
Publication number	US-10799705-B2
Application number	US-201815906206-A
Country	US
Kind code	B2
Filing date	Feb 27, 2018
Priority date	Aug 27, 2015
Publication date	Oct 13, 2020
Grant date	Oct 13, 2020

Abstract

Systems and methods for providing neural stimulation and recording on a subject using flexible complementary CMOS probes are provided. Disclosed systems can include a flexible probe adapted for insertion into a portion of a brain of the subject, the flexible probe comprising a tail portion and a head portion. The tail portion can include a plurality of electrodes configured to be coupled to the brain and a plurality of front-end amplifiers. Each of the plurality of front-end amplifiers can be configured to amplify a signal received from a corresponding electrode of the plurality of electrodes. The head portion can include one or more inductors configured to enable two-way communication with a wireless reader through a near-field inductive link.

First claim

What is claimed is:

1. A system for performing neural stimulation and recording in the nervous system of a subject, comprising:
a flexible probe comprising a tail portion and a head portion, wherein the tail portion is configured to be inserted into a cerebral cortex of the subject;
a flexible pliable single complementary-metal-oxide-semiconductor (CMOS) chip integrated into the tail portion;
one or more electrodes integrated into the CMOS chip; and
one or more inductors integrated into the head portion configured to provide wireless powering and data telemetry.

2. The system of claim 1 , further comprising
a plurality of front-end amplifiers integrated into the tail portion, wherein each of the plurality of front-end amplifiers is configured to amplify a signal received from a corresponding electrode of the one or more electrodes,
wherein the one or more inductors are configured to enable two-way wireless communication and adapted to be powered using a wireless external device.

3. The system of claim 1 , wherein the head portion further comprises:
data conversion circuitry configured to process signals received from each of the one or more electrodes for transmission to a wireless reader; and
power extracting circuitry configured to provide the flexible probe with energy received wirelessly from the wireless reader by the flexible probe by rectifying and boosting the received energy from the wireless reader,
wherein the data conversion circuitry and the power conversion circuitry are disposed under the one or more inductors.

4. The system of claim 3 , wherein the data conversion circuitry comprises a data encoder circuit configured to use near-field electromagnetic backscattering in a low megahertz to low gigahertz frequency range to enable power transfer and a high megahertz to low gigahertz frequency range to enable the two-way communication between the flexible probe and the wireless reader.

5. The system of claim 2 , wherein each of the plurality of front-end amplifiers comprises two CMOS transistors, wherein a gate terminal of at least one of the two CMOS transistors is input with the signal received from the corresponding electrode of the one or more electrodes.

6. The system of claim 2 , wherein the tail portion comprises (i) a plurality of metal layers and (ii) a plurality of analog signal chain circuits located on the metal layers, wherein each of the plurality of analog signal chain circuits comprises one of the plurality of front-end amplifiers.

7. The system of claim 6 , wherein each of the plurality of analog signal chain circuits is configured to process the signal received from the corresponding electrode of the one or more electrodes, and wherein signal outputs of at least two of the plurality of analog signal chain circuits are multiplexed, amplified, and converted into a digital signal by an analog to digital converter for transmission to the wireless reader.

8. The system of claim 1 , wherein the one or more electrodes are configured to detect an action potential by identifying an adjacent electrode from the one or more electrodes recording the action potential.

9. The system of claim 1 , wherein the tail portion comprises a scalable circuit architecture in which the number of electrodes in the one or more electrodes can be scaled to provide for an electrode to neuron ratio greater than 1.

10. The system of claim 3 , wherein the head portion of the flexible probe is oriented subdurally to communicate with the wireless reader.

11. A system for performing neural stimulation and recording in the nervous system of a subject, comprising:
a plurality of flexible probes, each of the flexible probes comprising a tail portion and a head portion, wherein the tail portion of each of the flexible probes is configured to be inserted into a cerebral cortex of the subject;
a plurality of flexible pliable single complementary-metal-oxide-semiconductor (CMOS) chips, wherein the tail portion of each of the flexible probes includes at least one CMOS chip of the plurality of CMOS chips integrated therein;
one or more electrodes integrated into each of the plurality of CMOS chips; and
one or more inductors configured to provide wireless powering and data telemetry.

12. The system of claim 11 , further comprising
a plurality of front-end amplifiers, wherein each of the plurality of front-end amplifiers is configured to amplify a signal received from a corresponding electrode of the one or more electrodes; and
wherein the one or more inductors are configured to enable two-way wireless communication and powering with a wireless reader through a near-field inductive link; and
the wireless reader is configured to provide power to the plurality of flexible probes and engage in two-way communication with each of the plurality of flexible probes.

13. The system of claim 12 , wherein different carrier frequencies are used by each of the plurality of probes to communicate with the wireless reader to prevent signal interference amongst the plurality of probes.

14. The system of claim 12 , wherein the head portion of each of the plurality of flexible probes further comprises:
data conversion circuitry configured to process signals received from each of the one or more electrodes for transmission to a wireless reader; and
power extracting circuitry configured to provide the flexible probe with energy received wirelessly from the wireless reader by the flexible probe by rectifying and boosting the received energy from the wireless reader,
wherein the data conversion circuitry and the power conversion circuitry are disposed under the one or more inductors.

15. The system of claim 12 , wherein each of the plurality of front-end amplifiers of each of the plurality of flexible probes comprises two CMOS transistors, wherein a gate terminal of at least one of the two CMOS transistors is input with the signal received from the corresponding electrode of the one or more electrodes.

16. The system of claim 12 , wherein the tail portion of each of the plurality of flexible probes comprises (i) a plurality of metal layers and (ii) a plurality of analog signal chain circuits located on the metal layers, and wherein each of the plurality of analog signal chain circuits comprises one of the plurality of front-end amplifiers.

17. The system of claim 16 , wherein each of the plurality of analog signal chain circuits of each of the plurality of flexible probes is configured to process the signal received from the corresponding electrode of the one or more electrodes, and wherein signal outputs of at least two of the plurality of analog signal chain circuits are multiplexed, amplified, and converted into a digital signal by an analog to digital converter for transmission to the wireless reader.

18. The system of claim 12 , wherein the one or more electrodes of each of the plurality of flexible probes are configured to detect an action potential in a dendritic field of the brain by identifying an adjacent electrode from the one or more electrodes in each flexible probe recording the action potential.

19. The system of claim 12 , wherein the tail portion of each of the plurality of flexible probes comprises a scalable circuit architecture in which the number of electrodes in the one or more electrodes can be scaled to provide for an electrode to neuron ratio greater than 1.

20. The system of claim 12 , wherein the head portion of each of the plurality of flexible probes is oriented subdurally to communicate with the wireless reader, an

Assignees

• Univ Columbia

Inventors

• Shepard Kenneth L
• Tsai David
• Kang Hongki
• Thimot Jordan

Classifications

• A61B5/291

  for electroencephalography [EEG] · CPC title

• A61N1/3787

  from an external energy source · CPC title

• A61B5/7225

  Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316) · CPC title

• A61N1/0531

  Brain cortex electrodes · CPC title

• A61B5/0031

  Implanted circuitry · CPC title