Injection device

Patent metadata

Field	Value
Publication number	US-10799646-B2
Application number	US-201414897360-A
Country	US
Kind code	B2
Filing date	Jun 11, 2014
Priority date	Jun 11, 2013
Publication date	Oct 13, 2020
Grant date	Oct 13, 2020

Abstract

An injection device for delivering an injection comprises a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end; and a release mechanism comprising an impediment, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede the delivery of the injection, and a second position, in which the impediment is in a non-impeding position so as to not impede the delivery of the injection, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

First claim

The invention claimed is:

1. An injection device for delivering an injection comprising:
a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end;
an activation mechanism adapted to commence the injection, the activation mechanism comprising a trigger configured to be moveable into an active position so as to effect the delivery of the injection; and
a release mechanism comprising an impediment that interacts with the trigger, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede movement of the trigger to the active position, and a second position, in which the impediment is in a non-impeding position so as to not impede movement of the trigger to the active position, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

2. An injection device according to claim 1 , wherein the release mechanism is resiliently biased towards the first position.

3. An injection device according to claim 1 , wherein the force profile exhibits an increasing force when the release mechanism is moved from the first position to the second position.

4. An injection device according to claim 1 , wherein the activation mechanism comprises a drive to provide the force required to deliver the injection.

5. An injection device according to claim 1 , wherein the injection device is configured to receive a syringe.

6. An injection device according to claim 2 , wherein the release mechanism comprises a moveable sleeve, the sleeve protruding from the distal end of the housing and moving proximally along the longitudinal axis of the housing when moving the release mechanism from the first position to the second position.

7. An injection device according to claim 3 , wherein the rate of increase in the force first increases and then decreases when the release mechanism is moved from the first position to the second position.

8. An injection kit comprising an injection device according to claim 5 ; and a syringe.

9. An injection device according to claim 6 , wherein the moveable sleeve protrudes from the distal end when in the first position and is flush with the housing when in the second position.

10. An injection device according to claim 6 , wherein the moveable sleeve comprises a resilient arm and the housing further comprises a camming surface inside the housing, the resilient arm being configured to ride along the camming surface as the moveable sleeve moves from the first position to the second position, the camming surface being configured such that the deformation of the resilient arm increases when the sleeve moves from the first position to the second position providing the resilient bias towards the first position.

11. An injection device according to claim 10 , wherein the camming surface is generally inclined towards the longitudinal axis of the housing.

12. An injection device according to claim 10 , wherein the camming surface is generally circumferentially inclined along the inner surface of the housing.

13. An injection device according to claim 10 , wherein the camming surface has an undulation to provide the non-linear force profile.

14. An injection device for delivering an injection comprising:
a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end;
an activation mechanism adapted to commence the injection, the activation mechanism comprising a trigger configured to be moveable into an active position so as to effect the delivery of the injection; and
a release mechanism comprising an impediment that interacts with the trigger, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede movement of the trigger to the active position, and a second position, in which the impediment is in a non-impeding position so as to not impede movement of the trigger to the active position, wherein the injection device produces an audible signal when the release mechanism is moved from the first position to the second position, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

15. A method of operating an injection device of any of claims 1 , 14 , 7 , or 4 - 5 comprising the steps of moving the release mechanism from the first position towards the second position; and
delivering the injection after detecting the non-linear nature of the force profile.

16. An injection device according to any one of claims 1 , 14 , 7 , or 4 - 5 or an injection kit according to claim 8 containing a substance selected from the group consisting of: golimumab, hormones, antitoxins, substances for the control of pain, substances for the control of thrombosis, substances for the control or elimination of infection, peptides, proteins, human insulin or a human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, antibodies, oligonucleotide, antiallergics, antihistamines, anti-inflammatories, corticosteroids, disease modifying anti-rheumatic drugs, erythropoietin, or vaccines, for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, toxicity, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anaemia, or myelodysplasia, or in the expression of protective immunity.

17. An injection device for use in the treatment or prevention rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, toxicity, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anaemia, or myelodysplasia, or in the expression of protective immunity, by delivery of a substance selected from the group consisting of: golimumab, hormones, antitoxins, substances for the control of pain, substances for the control of thrombosis, substances for the control or elimination of infection, peptides, proteins, human insulin or a human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, antibodies, oligonucleotide, antiallergics, antihistamines, anti-inflammatories, corticosteroids, disease modifying anti-rheumatic drugs, erythropoietin, or vaccines, to a human subject by using the injection device, wherein the injection device is an injection device according to any one of claims 1 , 14 , 7 , or 4 - 5 or an injection kit according to claim 8 .

Assignees

• Cilag Gmbh Int

Inventors

• Bitar Ahmad
• Jennings Douglas Ivan

Classifications

• A61M5/2033 Primary

  Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287) · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A61M5/3202

  Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001) · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61M2005/206

  With automatic needle insertion · CPC title