Biodegradable magnesium alloy nerve conduit for nerve defect repair and its preparation method

Patent metadata

Field	Value
Publication number	US-10792391-B2
Application number	US-201415775008-A
Country	US
Kind code	B2
Filing date	Jun 27, 2014
Priority date	Oct 17, 2013
Publication date	Oct 6, 2020
Grant date	Oct 6, 2020

Abstract

A biodegradable magnesium alloy nerve conduit for nerve defect repair has multiple lines of through holes in the tube wall thereof, the through holes in each line are axially arranged along a circular tube at equal distances, and the through holes in adjacent lines are arranged in a staggered way. A method for preparing the nerve conduit includes steps of: (step 1) processing a 45-degree conical surface at one end of a magnesium alloy tube blank, carrying out extrusion, and obtaining a magnesium alloy intermediate tube material; (step 2) obtaining a capillary tube after carrying out multi-pass rolling and drawing on the magnesium alloy intermediate tube material; (step 3) carrying out stress relief annealing on the capillary tube, laser cutting and punching, and obtaining a porous conduit; and (step 4) carrying out acid pickling on the porous conduit, and then carrying out electrochemical polishing treatment, and obtaining the nerve conduit.

First claim

What is claimed is:

1. A biodegradable magnesium alloy nerve conduit for nerve defect repair, wherein:
the biodegradable magnesium alloy nerve conduit has a circular cross-sectional area, a length in a range of 5-50 mm, and a thickness in a range of 0.1-0.2 mm;
the biodegradable magnesium alloy nerve conduit has multiple lines of through holes in a tube wall thereof, an aperture of each of the multiple lines of through holes is in a range of 0.03-0.3 mm, and a porosity of the nerve conduit is in a range of 2-20%;
each line of through holes are arranged along an axial direction of the nerve conduit at equal distances, and adjacent lines of through holes are arranged in a staggered way.

2. A method for preparing the biodegradable magnesium alloy nerve conduit for nerve defect repair according to claim 1 , wherein the method comprises steps of:
(S1) processing a 45-degree conical surface at one end of a magnesium alloy tube blank, spraying boron nitride on a mold and inner and outer walls of the magnesium alloy tube blank as a lubricant, carrying out extrusion, and obtaining a magnesium alloy intermediate tube material, wherein an outer diameter of the magnesium alloy tube blank is 20 mm, an extrusion temperature is in a range of 300-400° C., an outer diameter of the magnesium alloy intermediate tube material is in a range of 6-8 mm, and a wall thickness of the magnesium alloy intermediate tube material is in a range of 0.5-1 mm;
(S2) obtaining a capillary tube after carrying out multi-pass rolling and drawing on the magnesium alloy intermediate tube material, wherein an outer diameter of the capillary tube is in a range of 1-3 mm, and a wall thickness thereof is in range of 0.1-0.2 mm;
(S3) carrying out stress relief annealing on the capillary tube, laser cutting, punching, and obtaining a porous conduit, wherein a stress relief annealing temperature is in a range of 300-350° C., and an annealing time is in a range of 20-30 min; and
(S4) carrying out acid pickling on the porous conduit in an ultrasound cleaning machine with a pickling solution for 5-30 min, and then carrying out electrochemical polishing treatment with a polishing solution, and obtaining the biodegradable magnesium alloy nerve conduit for nerve defect repair, wherein the pickling solution comprises 80-100 ml/L of phosphoric acid and 40-60 g/L of ammonium bifluoride; a solvent is deionized water; the polishing solution comprises phosphoric acid and absolute ethanol with a volume ratio of 1:1 or comprises ethylene glycol monoethyl ether and hydrochloric acid with a volume ratio of 9:1; a polishing treatment voltage is in a range of 2-8 V, a polishing treatment time is in a range of 20-240 s, and a polishing treatment temperature is room temperature.

Assignees

• Univ Shanghai Jiaotong
• Shangdong Zhongbaokang Medical Devices Co Ltd

Inventors

• Yuan Guangyin
• Ding Wenjiang

Classifications

• A61L2430/32

  for nerve reconstruction · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61B17/1128

  of nerves · CPC title

• C22F1/06

  of magnesium or alloys based thereon · CPC title