Methods for enhancing mucosal innate immune responses to and/or detection of pathogens using human milk oligosaccharides

Patent metadata

Field	Value
Publication number	US-10792294-B2
Application number	US-201515302793-A
Country	US
Kind code	B2
Filing date	Apr 3, 2015
Priority date	Apr 8, 2014
Publication date	Oct 6, 2020
Grant date	Oct 6, 2020

Abstract

A method for enhancing an individual's mucosal innate immune response to pathogens is disclosed. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes about 0.05 to about 0.5 mg/mL 2′-fucosyllactose (2′-FL), about 0.05 to about 0.5 mg/mL lacto-N-neotetraose (LNnT), or a combination of both. Also disclosed is a method for enhancing an individual's mucosal innate immune detection of pathogens. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes a neutral human milk oligosaccharide.

First claim

The invention claimed is:

1. A method for stimulating expression of one or more of innate immune receptors and innate immune cytokines comprising administering a nutritional composition comprising about 0.05 mg/mL to about 0.5 mg/mL 2′-fucosyllactose (2′-FL), to an individual in need thereof, wherein the innate immune receptors are selected from the group consisting of TLR3, TLR4, and CCR2, and wherein the innate immune cytokine is IL1B, wherein stimulating expression of one or more of innate immune receptors and innate immune cytokines increases the individual's mucosal innate immune detection of pathogens.

2. The method of claim 1 , wherein the nutritional composition is a nutritional composition selected from liquid and powdered dietary supplements, liquid and powdered human milk fortifiers, liquid and powdered preterm infant formulas, liquid and powdered infant formulas, liquid and powdered elemental and semi-elemental formulas, liquid and powdered pediatric formulas, liquid and powdered toddler formulas, liquid and powdered follow-on formulas, and liquid, powdered and solid adult nutritional formulas.

3. The method of claim 1 , wherein the individual to whom the nutritional composition is administered has one or more of an enteric infection, inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, colitis, bowel obstruction, chronic stress, other gastrointestinal diseases, antibiotic therapy, radiation therapy, chemotherapy, surgery, other treatments or therapies; and dehydration.

4. The method of claim 1 , wherein the nutritional composition is a nutritional composition selected from liquid and powdered human milk fortifiers.

5. The method of claim 1 , wherein the nutritional composition is a nutritional composition selected from liquid and powdered preterm infant formulas.

6. The method of claim 1 , wherein the nutritional composition is a nutritional composition selected from liquid and powdered pediatric formulas.

7. The method of claim 1 , wherein the nutritional composition is a nutritional composition selected from liquid, powdered and solid adult nutritional formulas.

Assignees

• Abbott Lab

Inventors

• Buck Rachael
• Duska-Mcewen Geralyn
• Davis Steven

Classifications

• A61K31/702

  Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages · CPC title

• A61K31/7016 Primary

  Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032) · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A23L33/30

  Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence) · CPC title