Soft tissue in-growth of porous, three-dimensionally printed, transcutaneous implants of varying material and pore geometry
US-2018021139-A1 · Jan 25, 2018 · US
US10792129B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10792129-B2 |
| Application number | US-201615547899-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 3, 2016 |
| Priority date | Feb 3, 2015 |
| Publication date | Oct 6, 2020 |
| Grant date | Oct 6, 2020 |
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The present invention provides, among other things, implants including a biocompatible substrate, wherein the substrate includes a plurality of pores, such as trabecular and/or dodecahedral pores, and wherein said implant is configured as a transcutaneous implant. In some embodiments, provided implants may comprise multiple layers with differing pore densities, geometries, and/or distributions.
Opening claim text (preview).
We claim: 1. An implant comprising a biocompatible substrate including a first layer and a second layer, wherein said first layer comprises a plurality of pores, and said second layer comprises a plurality of pores, wherein the pores of said first layer have geometries that are different than the pores of said second layer, and wherein said implant is configured as a transcutaneous implant to remain in the skin and to facilitate skin tissue and/or subcutaneous tissue ingrowth. 2. The implant of claim 1 , wherein the pores of said first layer are regular and/or substantially uniform in at least one of size and shape. 3. The implant of claim 2 , wherein said regular and/or substantially uniform pores are dodecahedral. 4. The implant of claim 1 , wherein the pores of said second layer are regular and/or substantially uniform in at least one of size and shape. 5. The implant of claim 1 , wherein the pores of said first layer are irregular. 6. The implant of claim 1 , wherein the pores of said second layer are irregular. 7. The implant of claim 6 , wherein said irregular pores exhibit a trabecular or substantially trabecular geometry. 8. The implant of claim 1 , wherein said pores of said first layer are between 1-5,000 μm in diameter. 9. The implant of claim 1 , wherein said pores of said second layer are between 1-5,000 μm in diameter. 10. The implant of claim 1 , wherein the substrate comprises titanium, tantalum, a polymer, or a ceramic material. 11. The implant of claim 1 , wherein the substrate is coated with one or more growth factors.
Titanium or titanium alloys · CPC title
characterised by the material or composition, e.g. ceramics, surface layer, metal alloy (use of specific materials A61K6/00) · CPC title
Porous materials, {e.g. foams or sponges} · CPC title
having an open-celled or open-pored structure · CPC title
Titanium or titanium-based alloys, e.g. Ti-Ni alloys · CPC title
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