System and method for temporal sparse promoting imaging of cardiac activation

Patent metadata

Field	Value
Publication number	US-10791948-B2
Application number	US-201816103034-A
Country	US
Kind code	B2
Filing date	Aug 14, 2018
Priority date	Nov 18, 2013
Publication date	Oct 6, 2020
Grant date	Oct 6, 2020

Abstract

A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

First claim

The invention claimed is:

1. A system for cardiac activation imaging, the system comprising: at least one data acquisition device to acquire data relating to an electrical activation of a heart of a subject; and a processor configured to: receive the data acquired by the at least one data acquisition device, and generate a cardiac electrical activation image by reconstructing an activation image of the heart of the subject based on the acquired data and a weighted sparse constrained reconstruction, the reconstruction being sparse in a temporal domain, reconstructing the activation image of the heart further comprising generating temporal constraints to promote temporal weighted sparse constrained reconstructions that create a reconstructed peak, and cause the activation image of the heart to be displayed to the user.

2. The system of claim 1 , wherein the weighted sparse constrained reconstruction is non-sparse in a spatial domain and incorporates 4D spatiotemporal cardiac dynamics.

3. The system of claim 1 , wherein the processor, when reconstructing the activation image of the heart of the subject, is further configured to:
reconstruct the activation image of the heart of the subject based on a plurality of weights W t,i representing temporal weights of time instant t at location grid point i,
wherein the plurality of weights W t,i provide stability to the weighted sparse constrained reconstruction.

4. The system of claim 3 , wherein the plurality of weights W t,i are selected to provide at least one of a reduced smearing effect and a reduced distortion to the reconstructed activation image than a minimum norm solution.

5. The system of claim 3 , wherein the processor, when reconstructing the activation image of the heart of the subject, is further configured to:
generate guiding information C t,i representing an amplitude of current density at the time instant t and the location grid point i,
wherein C t,i indicates a likelihood that a cardiac electrical activation may occur, and
wherein the plurality of weights W t,i become larger as the guiding information C t,i becomes smaller.

6. The system of claim 3 , wherein the processor, when generating the temporal constraints, is further configured to:
generate the temporal constraints based on a body surface potential map and a structural map of the heart of the subject.

7. The system of claim 3 , wherein the processor, when receiving the data acquired by the at least one data acquisition device, is further configured to:
receive body surface ECG time courses measured by body surface electrodes as an input,
wherein the body surface ECG time courses are used as the temporal constraints in the temporal weighted sparse constrained reconstruction to identify a cardiac activation sequence.

8. The system of claim 3 , wherein the temporal weighted sparse constrained reconstruction includes an electrophysiologically based sparse property that protects against loss of information from the acquired data.

9. The system of claim 8 , wherein the electrophysiologically based sparse property is a temporal sparse property of cardiac electrical dynamics based on electrophysiological data from myocardial cellular depolarization.

10. The system of claim 1 , wherein the at least one data acquisition device comprises at least one of an electrocardiography (ECG) device or an interventional cardiac monitoring device.

11. A method for cardiac activation imaging, the method comprising:
obtaining, using a processor, data relating to an electrical activation of a heart of a subject obtained from at least one data acquisition device;
reconstructing, using the processor, an activation image of the heart of the subject based on the obtained data and a weighted sparse constrained reconstruction,
the reconstruction being sparse in a temporal domain, and
reconstructing the activation image of the heart further comprising generating temporal constraints to promote temporal weighted sparse constrained reconstructions that create a reconstructed peak; and

providing, using the processor, the activation image of the heart to a user.

12. The method of claim 11 , wherein the weighted sparse constrained reconstruction is non-sparse in a spatial domain and incorporates 4D spatiotemporal cardiac dynamics.

13. The method of claim 11 , wherein reconstructing the activation image of the heart of the subject further comprises:
reconstructing the activation image of the heart of the subject based on a plurality of weights W t,i representing temporal weights of time instant t at location grid point i,
wherein the plurality of weights W t,i provide stability to the weighted sparse constrained reconstruction.

14. The method of claim 13 , wherein the plurality of weights W t,i are selected to provide at least one of a reduced smearing effect and a reduced distortion to the reconstructed activation image than a minimum norm solution.

15. The method of claim 13 , wherein reconstructing the activation image of the heart of the subject further comprises:
generating guiding information C t,i representing an amplitude of current density at the time instant t and the location grid point i,
wherein C t,i indicates a likelihood that a cardiac electrical activation may occur, and
wherein the plurality of weights W t,i become larger as the guiding information C t,i becomes smaller.

16. The method of claim 13 , wherein generating the temporal constraints further comprises:
generating the temporal constraints based on a body surface potential map and a structural map of the heart of the subject.

17. The method of claim 13 , wherein the temporal weighted sparse constrained reconstruction includes an electrophysiologically based sparse property that protects against loss of information from the acquired data.

18. The method of claim 17 , wherein the electrophysiologically based sparse property is a temporal sparse property of cardiac electrical dynamics based on electrophysiological data from myocardial cellular depolarization.

19. The method of claim 11 , wherein obtaining data relating to an electrical activation of a heart of a subject obtained from at least one data acquisition device cause the processor to:
obtain data relating to the electrical activation of the heart of the subject obtained from at least one of an electrocardiography (ECG) device or an interventional cardiac monitoring device.

20. A non-transitory computer-readable medium storing instructions, the instructions comprising:
one or more instructions that, when executed by one or more processors, cause the one or more processors to
detect data relating to an electrical activation of a heart of a subject obtained from at least one data acquisition device;
reconstruct an activation image of the heart of the subject based on the detected data and a weighted sparse constrained reconstruction,
the reconstruction being sparse in a temporal domain, and
reconstructing the activation image of the heart further comprising generating temporal constraints to promote temporal weighted sparse constrained reconstructions that create a reconstructed peak; and

provide the activation image of the heart to a user.

21. The non-transitory computer-readable medium of claim 20 , wherein the weighted sparse constrained reconstruction is non-sparse in a spatial domain and incorporates 4D spatiotemporal cardiac dynamics.

22. The non-transitory computer-readable medium of claim 20 , wherein the o

Assignees

• Univ Minnesota

Inventors

• He Bin
• Yu Long

Classifications

• A61B5/346

  Analysis of electrocardiograms · CPC title

• A61B5/283

  Invasive · CPC title

• A61B5/367 Primary

  Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping · CPC title

• A61B5/282

  Holders for multiple electrodes (for introduction into the body A61B5/287) · CPC title

• A61B5/318

  Heart-related electrical modalities, e.g. electrocardiography [ECG] · CPC title