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Compounds and methods for activating the apoptotic arm of the unfolded protein response
US10787439B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10787439-B2 |
| Application number | US-201715672574-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 9, 2017 |
| Priority date | Jun 20, 2012 |
| Publication date | Sep 29, 2020 |
| Grant date | Sep 29, 2020 |
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Abstract
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N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
First claim
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What is claimed is: 1. A method of treating an oral squamous cell carcinoma, ovarian cancer or leukemia, in a subject comprising administering to a subject in need of treatment, a pharmaceutical composition comprising the compound: thereby treating the subject's oral squamous cell carcinoma, ovarian cancer or leukemia.
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not condensed and containing further heterocyclic rings, e.g. timolol · CPC title
containing a five-membered ring with oxygen as a ring hetero atom · CPC title
- C07D405/12Primary
linked by a chain containing hetero atoms as chain links · CPC title
of amides of sulfonic acids · CPC title
attached in position 5 · CPC title
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- What does patent US10787439B2 cover?
- N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
- Who is the assignee on this patent?
- Univ Kansas, Univ Michigan Regents, Univ Wayne State, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D405/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 29 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).