Method for treating surface of implant

Patent metadata

Field	Value
Publication number	US-10786602-B2
Application number	US-201314888592-A
Country	US
Kind code	B2
Filing date	Sep 24, 2013
Priority date	May 2, 2013
Publication date	Sep 29, 2020
Grant date	Sep 29, 2020

Abstract

Disclosed is a method for treating a surface of an implant. The disclosed method for treating the surface of the implant comprises the steps of: coating a surface treatment composition containing an organic material having a hydrophilic group on the surface of the implant (coating step); and drying the coated surface treatment composition (drying step).

First claim

What is claimed is:

1. A method for treating a surface of an implant, comprising: coating a surface treatment composition containing an organic material having a hydrophilic group and an inorganic salt on the surface of the implant (coating step); and drying the surface treatment composition including the organic material and the inorganic salt at a temperature less than 0° C. (drying step),
wherein the inorganic salt promotes the drying of the surface treatment composition in the drying step and allows the entire surface of the implant coated with the surface treatment composition to be dried at a uniform rate,
wherein a concentration of the inorganic salt in the surface treatment composition is 200 mM or less,
wherein the surface treatment composition is in an aqueous solution form,
wherein a solid substance derived from the organic material and the inorganic salt is left on the surface of the implant by the drying step,
wherein the method further comprises pre-treating the surface of the implant before the coating step (pre-treating step),
wherein the pre-treating step comprises UV treatment of the surface of the implant, and
wherein the organic material includes at least one selected from the group consisting of MES(2-(N-morpholino)ethanesulfonic acid), ADA(N-(carbamoylmethyl)iminodiacetic acid), PIPES(1,4-piperazinediethanesulfonic acid), ACES(2-(carbamoylmethylamino)ethanesulfonic acid), MOPSO(3-morpholino-2-hydroxypropanesulfonic acid), cholamine chloride, MOPS(3-morpholinopropane-1-sulfonic acid), BES(N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid), TES(2-[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]ethanesulfonic acid), HEPES(2-[4-(2-hydroxyethyl)piperazine-1-yl]ethanesulfonic acid), DIPSO(3-(N,N-bis[2-hydroxyethyl]amino)-2-hydroxypropanesulfonic acid), acetamido glycine, TAPSO(3-[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]-2-hydroxypropane-1-sulfonic acid), HEPPSO(N-(2-hydroxyethyl)piperazine-N′-(2-hydroxypropanesulfonic acid), HEPPS(4-(2-hydroxyethyl) -peperazine-1-propanesulfonic acid), Tricine(N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine), glycinamide, Bicine(2-bis(2-hydroxyethyl)amino)acetic acid), and TAPS(3-[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]propane-1-sulfonic acid).

2. The method of claim 1 , wherein the hydrophilic group includes at least one selected from the group consisting of a hydroxyl group (OH), a carboxyl group (COOH), an amino group (NH 2 ) and a sulfonic acid group (-SO 3 H).

3. The method of claim 1 , wherein the organic material further includes at least one selected from the group consisting of saccharides, proteins, and acids.

4. The method of claim 3 , wherein the saccharides includes at least one selected from the group consisting of glucose, cellulose, alkyl cellulose, alkyl hydroxyalkyl cellulose, hydroxyalkyl cellulose, cellulose sulfate, carboxymethyl cellulose salt, carboxymethyl cellulose, carboxyethyl cellulose, chitin, carboxymethyl chitin, hyaluronic acid, hyaluronic acid salt, alginate, alginic acid, propylene glycol alginate, glycogen, dextran, dextran sulfate, curdlan, pectin, pullulan, xanthan, chondroitin, chondroitin sulfates, carboxymethyl dextran, carboxymethyl chitosan, chitosan, heparin, heparin sulfate, heparan, heparan sulfate, dermatan sulfate, keratan sulfate, carrageenan, chitosan, starch, amylose, amylopectin, poly-N-glucosamine, polymannuronic acid, polyglucuronic acid, polyguluronic acid and derivatives of the saccharides.

5. The method of claim 3 , wherein the proteins includes at least one selected from the group consisting of gelatin, prothrombin, thrombin, fibrinogen, fibrin, fibronectin, heparinase, X factor, Xa factor, VII factor, VIIa factor, IX factor, IXa factor, XI factor, XIa factor, XII factor, XIIa factor, tissue factor, batroxobin, ancrod, ecarin, von Willebrand Factor, collagen, elastin, albumin, platelet surface glycoproteins, vasopressin, vasopressin analogs, epinephrine, selectin, procoagulant venom, plasminogen activator inhibitor, platelet activating factor and peptide.

6. The method of claim 3 , wherein the acids includes at least one selected from the group consisting of pyruvic acid, lactic acid, cysteine, glutamine, tyrosine, leucine, lycine, valine, isoleucine, threonine, phenilalanine, tryptophan, hystidine, arginine, glycine, serine, proline, glutamic acid, aspartic acid, alanine, methionine and asparagine.

7. The method of claim 1 , wherein the organic material comprises HEPES(2-[4-(2-hydroxyethyl)piperazine-1-yl]ethanesulfonic acid).

8. The method of claim 1 , wherein a concentration of the organic material in the surface treatment composition is 2,000 mM or less.

9. The method of claim 1 , wherein the inorganic salt includes at least one selected from the group consisting of metal chloride, metal phosphate, metal sulfate, metal carbonate and metal nitrate, and
wherein the metal in the inorganic salt includes at least one selected from the group consisting of sodium, calcium, potassium, strontium, manganese, and magnesium.

10. The method of claim 1 , wherein the implant comprises titanium or titanium alloy.

11. The method of claim 1 , further comprising heating the surface treatment composition after the drying step (post-treatment step).

12. The method of claim 11 , wherein the post-treatment step comprises heating the surface treatment composition at a temperature of 60° C.

13. A method for treating a surface of an implant, comprising: coating a surface treatment composition containing an organic material having a hydrophilic group and an inorganic salt on the surface of the implant (coating step); and drying the surface treatment composition including the organic material and the inorganic salt at a temperature less than 0° C. (drying step),
wherein the inorganic salt promotes the drying of the surface treatment composition in the drying step and allows the entire surface of the implant coated with the surface treatment composition to be dried at a uniform rate,
wherein a concentration of the inorganic salt in the surface treatment composition is 200 mM or less,
wherein the surface treatment composition is in an aqueous solution form,
wherein a solid substance derived from the organic material and the inorganic salt is left on the surface of the implant by the drying step,
wherein the method further comprises heating the surface treatment composition after the drying step (post-treatment step), and
wherein the organic material includes at least one selected from the group consisting of MES(2-(N-morpholino)ethanesulfonic acid), ADA(N-(carbamoylmethyl)iminodiacetic acid), PIPES(1,4-piperazinediethanesulfonic acid), ACES(2-(carbamoylmethylamino)ethanesulfonic acid), MOPSO(3-morpholino-2-hydroxypropanesulfonic acid), cholamine chloride, MOPS(3-morpholinopropane-1-sulfonic acid), BES(N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid), TES(2-[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]ethanesulfonic acid), HEPES(2-[4-(2-hydroxyethyl)piperazine-1-yl]ethanesulfonic acid), DIPSO(3-(N,N-bis[2-hydroxyethyl]amino)-2-hydroxypropanesulfonic acid), acetamido glycine, TAPSO(3-[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]-2-hydroxypropane-1-sulfonic acid), HEPPSO(N-(2-hydroxyethyl)piperazine-N′-(2-hydroxypropanesulfonic acid), HEPPS (4-(2-hydroxyethyl) -peperazine-1-propanesulfonic acid), Tricine(N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine), glycinamide, Bicine(2-bis(2-hydroxyethyl)amino)acetic acid), and TAPS(3[[1,3-dihydroxy-2-(hydroxymethyl)propane-2-yl]amino]propane-1-sulfonic acid).

14. The method of claim 13 , wherein the post-treatment step comprises heating the surface treatment composition

Assignees

• Osstem Implant Co Ltd

Inventors

• Ha Kyung Won
• Choi Kyoo Ok

Classifications

• A61L27/06 Primary

  Titanium or titanium alloys · CPC title

• A61C8/00

  Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools (fastening of peg-teeth in the mouth A61C13/30) · CPC title

• A61L27/28 Primary

  Materials for coating prostheses · CPC title

• A61L27/20

  Polysaccharides · CPC title

• A61C8/0013

  with a surface layer, coating · CPC title