Compositions and methods for plasmapheresis
US-2024277911-A1 · Aug 22, 2024 · US
US10786180B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10786180-B2 |
| Application number | US-201515515338-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 29, 2015 |
| Priority date | Sep 30, 2014 |
| Publication date | Sep 29, 2020 |
| Grant date | Sep 29, 2020 |
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A system and method for reducing intrafractional motion of a subject The system includes a subject user device, whereby the user device includes an image acquisition device configured to receive location marker information of the subject to provide location marking data of the subject. The system may also include a digital processor configured to: receive the location marking data and determine movement of the subject relative to the location marker information; and communicate feedback of the movement to the subject to help the subject reduce intrafractional motion.
Opening claim text (preview).
We claim: 1. A system for reducing intrafractional motion of a subject, the system comprising: a subject user device, said user device comprising: an image acquisition device configured to receive location marker information of the subject to provide location marking data of the subject; a digital processor configured to: receive said location marking data and determine movement of the subject relative to the location marker information, wherein said determination of movement of the subject is provided by configuring a geometric representation of rotation of the head of the subject, wherein said geometric representation of rotation of the head of the subject is provided according to the following characteristics: h, wherein h is the length of the head from the forehead to the back of the head, δ, wherein δ is the symbol of linear displacement, c, wherein c is the distance from said image acquisition device to a marker at δ=0, Δ, wherein Δ is the actual linear displacement of said marker caused by the head rotation of θ, Φ, wherein Φ is the angle of said image acquisition device seeing the displaced marker, d, wherein d is the distance from said image acquisition device to the marker at δ=Δ, and Ω, wherein Ω is the calculated displacement by the system; and communicate feedback of the movement to the subject to help the subject reduce intrafractional motion. 2. The system of claim 1 , wherein said communication feedback to the subject is in real time. 3. The system of claim 1 , wherein said communication feedback of the movement to the subject includes: visual display, audio signal, or both visual and audio. 4. The system of claim 3 , wherein said visual display is a display panel in communication with said subject user device and which is viewable by the subject. 5. The system of claim 4 , wherein said digital processor determines a reference point and a movement point, wherein: said reference point represents a starting position of the subject; and said movement point represents an indication of intrafractional motion of the subject. 6. The system of claim 4 , wherein display panel includes a display reference point and a display movement point, wherein: said reference point represents to a subject a starting position of the subject; and said display movement point represents to a subject an indication of intrafractional motion of the subject. 7. The system of claim 6 , wherein: said display reference point is a first color having a preselected pattern, and said display movement point is a second color having a preselected pattern, wherein the intrafractional motion causes the display movement point to move relative to the reference point, and that which is discernable to the subject. 8. The system of claim 3 , wherein said audio signal is provided by a speaker in communication with said subject user device and which is audible by the subject. 9. The system of claim 1 , further comprising: an operator device, said operator device comprising: an operator digital processor configured to communicate with said subject user device. 10. The system of claim 9 , wherein said operator digital processor is configured to control and/or monitor said user device. 11. The system of claim 9 , wherein said operator device comprises at least one of the following: video display, alpha-numeric input device, or UI navigation device for controlling or monitoring said user device. 12. The system of claim 1 , wherein said digital processor is configured to control said user device. 13. The system of claim 1 , wherein said location marker information of the subject is provided by the following: a marking substrate disposed on the subject; a location identified on the subject; or a combination of a marking substrate disposed on the subject and a location identified on the subject. 14. A computer implemented method for reducing intrafractional motion of a subject, the method comprising: receiving location marker information of the subject and generating location marking data of the subject; digitally processing said location marking data and determining movement of the subject relative to the location marker information, wherein said determination of movement of the subject is provided by configuring a geometric representation of rotation of the head of the subject, wherein said geometric representation of rotation of the head of the subject is provided according to the following characteristics: h, wherein h is the length of the head from the forehead to the back of the head, δ, wherein δ is the symbol of linear displacement, c, wherein c is the distance from said image acquisition device to a marker at δ=0, Δ, wherein Δ is the actual linear displacement of said marker caused by the head rotation of θ, Φ, wherein Φ is the angle of said image acquisition device seeing the displaced marker, d, wherein d is the distance from said image acquisition device to the marker at δ=Δ, and Ω, wherein Ω is the calculated displacement by the system; and communicating feedback of the movement to the subject to help the subject reduce intrafractional motion. 15. The method of claim 14 , wherein said communicating the feedback to the subject is performed in real time. 16. The method of claim 14 , wherein said communicating the feedback of the movement to the subject includes: visually displaying said feedback to the subject, audibly signaling said feedback to the subject, or both visually displaying and audibly signaling to the subject. 17. The method of claim 14 , wherein said digital processing determines a reference point and a movement point, wherein: said reference point represents a starting position of the subject; and said movement point represents an indication of intrafractional motion of the subject. 18. The method of claim 17 , wherein: said reference point is associated with a first alarm having a preselected audible tone or pitch, and said movement point is associated with a second alarm having a preselected audible tone or pitch, wherein the intrafractional motion causes the second alarm to activate, which is audibly discernable to the subject. 19. The method of claim 14 , further comprising: operating a controller, wherein operating the controller includes controlling said digital processing and/or said communicating of the feedback. 20. The method of claim 19 , wherein said operating the controller is performed with at least one of the following: video display, alpha-numeric input device, or UI navigation device. 21. The method of claim 14 , wherein said location marker information of the subject is provided by the following: providing a marking substrate disposed on the subject; identifying a location on the subject; or a combination of providing a marking a substrate disposed on the subject and identifying a location on the subject. 22. A non-transitory machine readable medium including instructions for reducing intrafractional motion of a subject, which when executed by a machine, cause the machine to: receive location marker information of the subject and generate location marking data of the subject; determine movement of the subject relative to the location marker information, wherein said determination of movement of the subject is provided by configuring a geometric representation of rotation of the head of the subject, wherein said geometric representation of rotation of the head of the subject is provided a
in real time, i.e. during treatment · CPC title
occurring during breathing · CPC title
Visible markers · CPC title
involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title
using cameras imaging the patient · CPC title
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