Skull implanted electrode assembly for brain stimulation

Patent metadata

Field	Value
Publication number	US-10780264-B2
Application number	US-201816109148-A
Country	US
Kind code	B2
Filing date	Aug 22, 2018
Priority date	Sep 27, 2016
Publication date	Sep 22, 2020
Grant date	Sep 22, 2020

Abstract

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising a conductor housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

First claim

The invention claimed is:

1. A method of treating a medical ailment of a patient with an implantable electrode assembly, the method comprising:
implanting the implantable electrode assembly into a skull of the patient, wherein the implantable electrode assembly comprises:
an electrically-conductive cannulated skull screw with a head end and a point end, which transverses the skull of the patient with the point end located at an interior surface of the skull and the head end located at an exterior surface of the skull,
an electronics module comprising a casing, wherein the electronics module is electrically connected to the head end of the skull screw and wherein the casing is in direct contact with the head end of the skull screw,
a conductor housed in an insulated conduit and threaded through the skull screw, said conductor comprising a connection end and an electrode end, with the connection end located at the head end of the skull screw and electrically connected to the electronics module,
a flexible insulator housing three conductive discs having diameters of 0.2-3 mm arranged linearly with an equal spacing of 4-12 mm for a total length of 3.5-9 cm, wherein each conductive disc is wired independently and electrically connected to the electrode end;

forming three electrical connections with the conductive discs and different locations of the patient's brain tissue; and
continuously generating pulses of current between the conductive discs and the skull screw to inhibit the release of neurotransmitters, wherein the pulses have square pulse shapes with pulse widths of 55 μs-200 ms, frequencies of 20-160 Hz, and voltages of 0.4-4.5 V,
wherein the medical ailment is at least one selected from the group consisting of epilepsy, migraine, depression, anxiety, attention deficit disorder, hyperactivity, bipolar disorder, stroke, dementia, schizophrenia, delirium, neurosis, psychosis, Parkinson's disease, alcohol withdrawal, drug withdrawal, dizziness, motion sickness, insomnia, dystonia, chronic pain, obsessive compulsive disorder, Tourette's syndrome, essential tremor, spasticity, trigeminal neuralgia, and headache.

2. The method of claim 1 , further comprising:
generating additional pulses of current between two of the three conductive discs with pulse widths of 55 μs-200 ms, frequencies of 20-160 Hz, and voltages of 0.4-4.5 V, wherein the additional pulses are sine waves.

3. The method of claim 2 , wherein the medical ailment is motion sickness.

4. The method of claim 3 , further comprising drilling a hole into the patient's skull before the implanting.

5. The method of claim 3 , further comprising monitoring the amount of current delivered by the pulses of current and the additional pulses of current.

6. The method of claim 3 , further comprising stimulating the brain tissue with pulses of magnetic fields, wherein the electrode end of the conductor comprises an electromagnet.

7. The method of claim 2 , wherein the medical ailment is both anxiety and chronic pain.

8. The method of claim 7 , wherein the generating additional pulses of current between the two of the three conductive discs is done for 20-60 minutes every two hours.

9. The method of claim 7 , further comprising drilling a hole into the patient's skull before the implanting.

10. The method of claim 7 , further comprising stimulating the brain tissue with pulses of magnetic fields, wherein the electrode end of the conductor comprises an electromagnet.

11. The method of claim 2 , further comprising implanting a receptacle for the skull screw into the patient's skull before the implanting the implantable electrode assembly.

12. The method of claim 2 , wherein the generating additional pulses of current between the two of the three conductive discs is done continuously.

13. The method of claim 12 , wherein the medical ailment is dementia.

14. The method of claim 2 , wherein the medical ailment is insomnia, and one conductive disc forms an electrical connection with a brain tissue of Broadman Area 4.

15. The method of claim 1 , further comprising:
removing the electronics module while leaving the conductor and cannulated skull screw in place; and
attaching a second electronics module.

16. The method of claim 15 , wherein the electronics module is removed without having to use specialized tools.

17. The method of claim 16 , wherein the insulated conduit is removably attached to the head end of the skull screw by a key and keyhole mechanism, wherein the insulated conduit comprises a key and the head end of the skull screw comprises a complementary keyhole.

18. The method of claim 15 , wherein the electronics module and the second electronics module each further comprises a battery, and the second electronics module has a greater battery charge.

Assignees

• Nat Guard Health Affairs
• King Saud Bin Abdulaziz Univ For Health Sciences
• King Abdullah International Medical Res Center
• King Saud Bin Abdulaziz Univ For Health Science

Inventors

• Alam Imran Khurshid

Classifications

• A61B5/293

  Invasive · CPC title

• A61N1/3787

  from an external energy source · CPC title

• A61N1/36139

  with automatic adjustment · CPC title

• A61N1/3606

  adapted for a particular treatment · CPC title

• A61N1/37514

  Brain implants · CPC title