Aqueous solution containing n-long-chain acyl acidic amino acid and/or salt thereof, and method for producing same

Patent metadata

Field	Value
Publication number	US-10780167-B2
Application number	US-201816177847-A
Country	US
Kind code	B2
Filing date	Nov 1, 2018
Priority date	Oct 31, 2013
Publication date	Sep 22, 2020
Grant date	Sep 22, 2020

Abstract

The present invention provides a method of producing an aqueous solution containing an N—C8-22 acyl acidic amino acid and/or a salt thereof and having pH 8.4-9.5, including the first step for reacting an acidic amino acid and/or a salt thereof with a C8-22 fatty acid chloride in a water solvent at pH 10-13 to form an N—C8-22 acyl acidic amino acid salt, and the second step for adjusting the pH of the aqueous solution after the first step to 8.4-9.5.

First claim

The invention claimed is:

1. A method of producing an aqueous solution,
said aqueous solution comprising at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid and a salt of an N—C 8-22 aliphatic acyl acidic amino acid and having pH 8.4 to 9.5,
said method comprising:
(i) reacting at least one member selected from the group consisting of glutamic acid, aspartic acid, a salt of glutamic acid and a salt of aspartic acid, with a C 8-22 fatty acid chloride in a water solvent at pH 10 to 13 to obtain an aqueous solution comprising said at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid and a salt of an N—C 8-22 aliphatic acyl acidic amino acid; and
(ii) adjusting the pH of said aqueous solution to a value of 8.4 to 9.5;
wherein said water solvent is water or a mixed solvent of a hydrophilic organic solvent and water; and
wherein said mixed solvent comprises said hydrophilic organic solvent in a content of not more than 5 wt % of said mixed solvent.

2. The method according to claim 1 , further comprising:
(iii) pressure filtering said aqueous solution.

3. The method according to claim 1 , wherein said aqueous solution comprises:
1.0 to 10.0 wt % of said at least one member selected from the group consisting of glutamic acid, aspartic acid, a salt of glutamic acid and a salt of aspartic acid, based on the total weight of said aqueous solution; and
10.0 to 30.0 wt % of said at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid and a salt of an N—C 8-22 aliphatic acyl acidic amino acid, based on the total weight of said aqueous solution.

4. The method according to claim 2 , wherein said aqueous solution comprises:
1.0 to 10.0 wt % of said at least one member selected from the group consisting of glutamic acid, aspartic acid, a salt of glutamic acid and a salt of aspartic acid, based on the total weight of said aqueous solution; and
10.0 to 30.0 wt % of said at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid and a salt of an N—C 8-22 aliphatic acyl acidic amino acid, based on the total weight of said aqueous solution.

5. The method according to claim 1 , wherein said aqueous solution further comprises at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid dipeptide and a salt of an N—C 8-22 aliphatic acyl acidic amino acid dipeptide.

6. The method according to claim 5 , wherein said aqueous solution comprises said at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid dipeptide and a salt of an N—C 8-22 aliphatic acyl acidic amino acid dipeptide in an amount of 0.5 to 5.0 wt %, based on the total weight of said aqueous solution.

7. The method according to claim 1 , wherein said aqueous solution further comprises at least one member selected from the group consisting of an N—C 8-22 aliphatic acyl acidic amino acid tripeptide and a salt of an N—C 8-22 aliphatic acyl acidic amino acid tripeptide.

8. The method according to claim 1 , wherein said aqueous solution further comprises at least one member selected from the group consisting of a N—C 8-22 fatty acid and a salt of a N—C 8-22 fatty acid.

9. The method according to claim 1 , further comprising:
(iii′) packing said aqueous solution in a container.

Assignees

• Ajinomoto Kk

Inventors

• Hattori Gaku
• Ishii Hiroji
• Ino Masahiro

Classifications

• A61K8/44 Primary

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• A61Q5/02

  Preparations for cleaning the hair · CPC title

• C07C231/02

  from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines · CPC title

• C07C233/49

  having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton · CPC title

• C11D17/041

  Compositions releasably affixed on a substrate or incorporated into a dispensing means · CPC title