In situ forming hydrogel and method using same

Patent metadata

Field	Value
Publication number	US-10780145-B2
Application number	US-201715840621-A
Country	US
Kind code	B2
Filing date	Dec 13, 2017
Priority date	Oct 12, 2011
Publication date	Sep 22, 2020
Grant date	Sep 22, 2020

Abstract

A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.

First claim

We claim:

1. A polymer for preparing a hydrogel, wherein the polymer is poly(NIPAAm-co-DBLA-co-JAAm) having a structure of:

wherein:
R1 and R2 are independently selected from the group consisting of H, alkyl, phenyl, benzyl, 2-cyanoprop-2-yl, 4-cyanopentanoic acid-4-ylethyl-2-propionate, sulfate, 2-[2-methoxypropan-2-yl)oxy]propan-2-yl, and 4-cyano-4-(ethylsulfanylthiocarbonyl)sulfanylpentanoic acid;
a is about 10 to about 1,000, b is about 1 to about 250, and c is about 1 to about 500, and units of a, units of b, and units of c are arranged randomly and/or in blocks;
a ratio of r:p is 19:3; and
r is about 5 to about 2,500 and p is about 1 to about 1,000, and units of r and units of p are arranged randomly.

2. The polymer of claim 1 , wherein the units of r and the units of p are a random copolymer with a weight of about 1,000 Da.

3. The polymer of claim 1 , comprising the DBLA at about 4.7 mol % and JAAm at about 2.9 mol %.

4. The polymer of claim 1 , the polymer having a number average molecular weight Mn of about 13,100 g/mol.

5. The polymer of claim 1 , the polymer having a weight average molecular weight Mw of about 28,200 g/mol.

6. A hydrogel comprising:
the polymer of claim 1 ; and
water.

7. The hydrogel of claim 6 , wherein the units of r and the units of p are a random copolymer with a weight of 1,000 Da.

8. The hydrogel of claim 6 , comprising the DBLA at about 4.7 mol % and JAAm at about 2.9 mol %.

9. The hydrogel of claim 6 , the polymer having a number average molecular weight Mn of about 13,100 g/mol.

10. The hydrogel of claim 6 , the polymer having a weight average molecular weight Mw of about 28,200 g/mol.

Assignees

• Univ Arizona State
• Banner Health
• Arizona Board Of Regents A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizon

Inventors

• Overstreet Derek
• Vernon Brent
• Mclemore Ryan
• Mclaren Alex

Classifications

• A61K9/06 Primary

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61K38/14 Primary

  Peptides containing saccharide radicals; Derivatives thereof {, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin} · CPC title