Femtowatt non-vacuum tube detector assembly

Patent metadata

Field	Value
Publication number	US-10778167-B2
Application number	US-201816001780-A
Country	US
Kind code	B2
Filing date	Jun 6, 2018
Priority date	Mar 15, 2013
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

In one embodiment, a femtowatt sensitivity optical detector is provided using one or more photodiodes, intended as a replacement for the photomultiplier based photon counting unit.

First claim

What is claimed is:

1. A device comprising:
a plurality of photodiodes;
an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs; and
a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory, wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;
wherein the device detects signals at femtowatt sensitivity.

2. The device of claim 1 further comprising a mechanical housing module of the analog amplification system are contained.

3. The device of claim 1 further comprising at least one shaped reflector to direct light to at least one of said photodetectors.

4. The device of claim 3 wherein the shaped reflector has a semi-hemispherical shape.

5. The device of claim 3 wherein the shaped reflector comprises at least one opening sized and positioned to allow a sample vessel to be placed at a desired location in a cavity defined at least in part by the shaped reflector.

6. A device comprising:
a plurality of photodiodes;
an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs;
a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory,
wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;
wherein the device detects signals at femtowatt sensitivity; and
a plurality of digital-to-analog converters (DACs) on the programmable processor configured to provide feedback control.

7. A device comprising:
a plurality of photodiodes;
an analog amplification system comprising at least a high gain transimpedance amplifier (TIA) and at least a buffer on each of said photodiodes, followed by a fully differential amplifier to combine outputs of multiple TIAs;
a digital acquisition system comprising at least one analog-to-digital converter (ADC), followed by a programmable processor, which is linked to a central processor as well as on-board memory,
wherein the programmable processor implements a data acquisition algorithm, wherein the programmable processor implements the data acquisition algorithm using a long time average;
wherein the device detects signals at femtowatt sensitivity; and
a plurality of digital-to-analog converters (DACs) on the programmable processor configured to provide feedback control, wherein one of said DACs is configured for offset adjustment in the differential amplifier, and one of said DACs is set the reference level of the ADC.

Assignees

• Theranos Ip Co Llc
• Labrador Diagnostics Llc

Inventors

• Mohan Karan
• Martinez Marcelo

Classifications

• H10F77/953 Primary

  for devices having potential barriers · CPC title

• G01N2015/1006

  for cytology · CPC title

• H03F3/08

  controlled by light · CPC title

• H03M1/0607

  Offset or drift compensation (removal of offset already present on the analogue input signal H03M1/1295) · CPC title

• G01N15/1434

  Optical arrangements · CPC title