Electromechanical approach for cancer detection

Patent metadata

Field	Value
Publication number	US-10775336-B2
Application number	US-201615238795-A
Country	US
Kind code	B2
Filing date	Aug 17, 2016
Priority date	Dec 5, 2015
Publication date	Sep 15, 2020
Grant date	Sep 15, 2020

Abstract

An electrical probe is disclosed for measuring an electrical response from a biological cell. The electrical probe includes a tungsten microwire having a sharpened tip section, a catalyst layer formed on the sharpened tip section of the tungsten microwire, and an array of nanotube electrodes vertically aligned on the catalyst layer. The catalyst layer includes a catalyst bilayer including a nickel layer over a gold layer, and the nanotube electrodes include a plurality of silicon nanotubes (SiNTs).

First claim

What is claimed is:

1. An electrical probe for measuring an electrical response from a biological cell, comprising:
a tungsten microwire with a diameter less than 500 μm with a sharpened tip section, the sharpened tip section with a sharp pointed tip with a diameter of 200 nm or less;
a catalyst layer formed on the sharpened tip section of the tungsten microwire, the catalyst layer comprising a catalyst bilayer comprising a nickel layer with a thickness in a range between 10 nm and 40 nm over a gold layer with a thickness in a range between 1 nm and 4 nm;
an array of nanotube electrodes vertically aligned on the catalyst layer, the nanotube electrodes comprising a plurality of doped silicon nanotubes (SiNTs) comprising a long free-end silicon nanotube located on a tip of the sharpened tip section being longer than remaining SiNTs of the plurality of doped SiNTs; and
a gold layer coated over the plurality of doped SiNTs with a thickness of 5 nm, wherein the long free-end silicon nanotube is configured to connect with and penetrate into a single biological cell.

2. The electrical probe according to claim 1 , wherein the plurality of doped SiNTs comprises a plurality of doped SiNTs with phosphorus.

Assignees

• Abdolahad Mohammad
• Saeidi Ali
• Gharooni Milad

Inventors

• Abdolahad Mohammad
• Saeidi Ali
• Gharooni Milad

Classifications

• C23C28/322

  only coatings of metal elements only · CPC title

• C25F3/08

  of refractory metals · CPC title

• C23C14/16

  on metallic substrates or on substrates of boron or silicon · CPC title

• C23C28/321

  with at least one metal alloy layer · CPC title

• C23C28/34

  including at least one inorganic non-metallic material layer, e.g. metal carbide, nitride, boride, silicide layer and their mixtures, enamels, phosphates and sulphates · CPC title